Evidence map›Paper›PMID 40870038›Full record

ArticleGenes2025

Transcriptional Regulation of CYP2E1: Promoter Methylation in In Vitro Models and Human Liver Disease Samples.

Nina Komaniecka, Mateusz Kurzawski, Sylwia Szeląg-Pieniek, Joanna Łapczuk-Romańska, Mariola Post, Urszula Adamiak-Giera, Marek Droździk

Abstract read
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nina KomanieckaDepartment of Experimental and Clinical Pharmacology, Pomeranian Medical University, 70-111 Szczecin, Poland.ORCID 0009-0006-3162-4870
Mateusz KurzawskiLaboratory of Pharmacodynamics, Pomeranian Medical University in Szczecin, 71-899 Szczecin, Poland.
Sylwia Szeląg-PieniekDepartment of Experimental and Clinical Pharmacology, Pomeranian Medical University, 70-111 Szczecin, Poland.
Joanna Łapczuk-RomańskaDepartment of Experimental and Clinical Pharmacology, Pomeranian Medical University, 70-111 Szczecin, Poland.ORCID 0000-0002-2027-0687
Mariola PostDepartment of General and Transplant Surgery, Pomeranian Regional Hospital, 71-455 Szczecin, Poland.
Urszula Adamiak-GieraDepartment of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, 70-111 Szczecin, Poland.
Marek DroździkDepartment of Experimental and Clinical Pharmacology, Pomeranian Medical University, 70-111 Szczecin, Poland.ORCID 0000-0002-6191-7168

Funding

National Science Centre UMO-2020/37/B/NZ7/01466
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cytochrome P-450 CYP2E1DNA MethylationLiver DiseasesPromoter Regions, GeneticCaco-2 CellsDecitabineEpigenesis, GeneticFemaleGene Expression RegulationHep G2 CellsHumansIntestinal MucosaLiverMaleMiddle AgedCytochrome P-450 CYP2E1Decitabinecytochrome P450 2E1drug metabolismepigenetic regulationhuman studyliver pathology

Identifiers

PMID40870038
PMCPMC12385311

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.