Interaction Between Vitamin D Metabolism Genetic Variants: Association with Hypovitaminosis D, Rheumatoid Arthritis, and Its Clinical Disease Activity.
Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors.
Bertha Campos-LópezRed de Inmunonutrición y Genómica Nutricional en las Enfermedades Autoinmunes; Departamento de Neurociencias, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0002-1667-8794
Melissa Rivera-EscotoRed de Inmunonutrición y Genómica Nutricional en las Enfermedades Autoinmunes; Departamento de Neurociencias, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0001-9069-7478
Adolfo I Ruiz-BallesterosRed de Inmunonutrición y Genómica Nutricional en las Enfermedades Autoinmunes; Departamento de Neurociencias, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0001-8993-6312
Karen Pesqueda-CendejasRed de Inmunonutrición y Genómica Nutricional en las Enfermedades Autoinmunes; Departamento de Neurociencias, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0002-6849-5965
Paulina E Mora-GarcíaRed de Inmunonutrición y Genómica Nutricional en las Enfermedades Autoinmunes; Departamento de Neurociencias, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0002-5452-6222
Mónica R Meza-MezaRed de Inmunonutrición y Genómica Nutricional en las Enfermedades Autoinmunes; Departamento de Neurociencias, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0003-4991-4965
Isela Parra-RojasRed de Inmunonutrición y Genómica Nutricional en las Enfermedades Autoinmunes; Departamento de Neurociencias, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0002-9213-8263
José M Moreno-OrtízInstituto de Genética Humana "Dr. Enrique Corona Rivera", Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0001-7555-9851
Eneida Turiján-EspinozaRed de Inmunonutrición y Genómica Nutricional en las Enfermedades Autoinmunes; Departamento de Neurociencias, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.
Juan M Vargas-MoralesRed de Inmunonutrición y Genómica Nutricional en las Enfermedades Autoinmunes; Departamento de Neurociencias, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.
Sergio Cerpa-CruzDepartamento de Reumatología, O.P.D. Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara 44280, Jalisco, Mexico.
Ulises De la Cruz-MossoRed de Inmunonutrición y Genómica Nutricional en las Enfermedades Autoinmunes; Departamento de Neurociencias, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0003-4579-2294
Funding
Programa de Apoyo a la Mejora en las Condiciones de Producción de los Miembros del SNI y SNCA 2019-2025 U.D.l.C.-M.Programa de Impulso a la Investigación (PIN) 2024-V U.D.l.C.-M.
6 · The paper itself
Abstract
backgroundHypovitaminosis D has been associated with worse rheumatoid arthritis (RA) manifestations. Notably, different genetic studies have reported that approximately 65% of hypovitaminosis D can be partially explained using the presence of single-nucleotide variants (SNVs) in key genes involved in its metabolism. This study aimed to investigate the association and gene-gene interactions of four SNVs in vitamin D metabolism genes, rs10741657 (
methodsThis study was conducted among females: 204 RA patients and 204 control subjects (CS). Vitamin D serum levels (calcidiol) were analyzed using ELISA, SNVs through allelic discrimination with TaqMan
resultsMDR analysis suggested that GG and TT genotypes of rs10877012 (
conclusionsThe GG genotype of rs10877012
Indexed as
25-Hydroxyvitamin D3 1-alpha-HydroxylaseArthritis, RheumatoidPolymorphism, Single NucleotideReceptors, CalcitriolVitamin DVitamin D3 24-HydroxylaseVitamin D DeficiencyAdultAgedCase-Control StudiesCholestanetriol 26-MonooxygenaseCytochrome P450 Family 2Epistasis, GeneticFemaleGenetic Predisposition to DiseaseGenotype25-Hydroxyvitamin D3 1-alpha-HydroxylaseCholestanetriol 26-MonooxygenaseCYP24A1 protein, humanCYP27B1 protein, humanCYP2R1 protein, humanCytochrome P450 Family 2Receptors, CalcitriolVDR protein, humanVitamin DVitamin D3 24-HydroxylaseCYP27B1genetic variantshypovitaminosis Dmultifactor dimensionality reduction (MDR)rheumatoid arthritisvitamin Dvitamin D genesvitamin D receptor
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Interaction Between Vitamin D Metabolism Genetic Variants: Association with Hypovitaminosis D, Rheumatoid Arthritis, and Its Clinical Disease Activity. · full record | OpenQuestion