Evidence map›Paper›PMID 40870001›Full record

ArticleGenes2025

Mitochondrial Genome and RNA Editing Tissue Specificity of

Cuihong Yang, Wenjing Liang, Ya Qin, Yuqiong Li, Shugen Wei, Qiulan Huang, Ahmed H El-Sappah, Guiyu Tan, Ying Wei, Lingjian Gui and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The multichromosomal structure evolution ofFrontiers in plant science · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cuihong YangGuangxi Key Laboratory for High-Quality Formation and Utilization of Dao-di Herbs, Guangxi Botanical Garden of Medicinal Plants, Nanning 530023, China.
Wenjing LiangGuangxi Key Laboratory for High-Quality Formation and Utilization of Dao-di Herbs, Guangxi Botanical Garden of Medicinal Plants, Nanning 530023, China.
Ya QinGuangxi Key Laboratory for High-Quality Formation and Utilization of Dao-di Herbs, Guangxi Botanical Garden of Medicinal Plants, Nanning 530023, China.
Yuqiong LiGuangxi Key Laboratory for High-Quality Formation and Utilization of Dao-di Herbs, Guangxi Botanical Garden of Medicinal Plants, Nanning 530023, China.
Shugen WeiGuangxi Key Laboratory for High-Quality Formation and Utilization of Dao-di Herbs, Guangxi Botanical Garden of Medicinal Plants, Nanning 530023, China.
Qiulan HuangFaculty of Agriculture, Forestry and Food Engineering, Yibin University, Yibin 644000, China.
Ahmed H El-SappahFaculty of Agriculture, Forestry and Food Engineering, Yibin University, Yibin 644000, China.
Guiyu TanGuangxi Key Laboratory for High-Quality Formation and Utilization of Dao-di Herbs, Guangxi Botanical Garden of Medicinal Plants, Nanning 530023, China.ORCID 0000-0003-0574-0617
Ying WeiGuangxi Key Laboratory for High-Quality Formation and Utilization of Dao-di Herbs, Guangxi Botanical Garden of Medicinal Plants, Nanning 530023, China.
Lingjian GuiGuangxi Key Laboratory for High-Quality Formation and Utilization of Dao-di Herbs, Guangxi Botanical Garden of Medicinal Plants, Nanning 530023, China.
Lingyun WanNational Center for Traditional Chinese Medicine (TCM) Inheritance and Innovation, Guangxi Botanical Garden of Medicinal Plants, Nanning 530023, China.ORCID 0000-0002-1780-0413

Funding

Natural Science Foundation of Guangxi Province (2023GXNSFAA026330), Gaungxi Bagui Brilliance Visiting Scholar Program (Lingyun Wan), Guangxi Science and Technology Base and Special Talents (Guike AD22035026), Innovative Team for Traditional Chinese Medici (2023GXNSFAA026330); (Guike AD22035026); (GZKJ2305); (GZSY23-02); (ZJC2020003)
6 · The paper itself

Abstract

background

methodsAssembly using Illumina short-reads and Nanopore long-reads was used to characterize the mitochondrial genome. Analyses included structural characterization, codon usage bias, repetitive sequences, horizontal gene transfer (HGT), collinearity, and phylogeny. The resulting tissue-specific (root, stem, and leaf) long non-coding RNA (lncRNA) profiles identified RNA editing sites.

resultsThe complete mitochondrial genome (249,777 bp, 45.5% GC) comprises three circular contigs encoding 51 genes (33 protein-coding, 15 tRNA, and 3 rRNA). Comparative genomics revealed synteny with the Apiaceae family of plants and evidence of HGT. Phylogenetic analysis resolved taxonomic relationships within Apiales. We predicted that 547 RNA editing sites would be identified in its protein-coding genes. Tissue profiling identified 725 (root), 711 (stem), and 668 (leaf) editing sites, with >71% concordance to predictions. RNA editing-generated cryptic promoters/terminators occur in mitochondrial core function genes (e.g., ATP synthase, cytochrome c reductase/oxidase, ribosome large subunit, and cytochrome c biogenesis), exhibiting a lower frequency in the leaves compared to the roots and stems.

conclusionsWe provide the first complete mitochondrial genome assembly for

Indexed as

CentellaGenome, MitochondrialRNA EditingEvolution, MolecularGene Transfer, HorizontalOrgan SpecificityPhylogenyRNA, Long NoncodingRNA, TransferRNA, Long NoncodingRNA, TransferCentella asiaticamitochondrionRNA editing

Identifiers

PMID40870001
PMCPMC12385686

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.