Gene Mutation-Negative Malignant Melanoma in a Prepubertal Patient: A Clinical and Molecular Case Report.

Adrian Guźniczak, Patrycja Sosnowska-Sienkiewicz, Jarosław Szydłowski, Paweł Kurzawa, Danuta Januszkiewicz-Lewandowska

Abstract readCase Reports

In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Adrian GuźniczakFaculty of Medicine, Poznan University of Medical Sciences, Fredry 10 Street, 61-701 Poznan, Poland.ORCID 0009-0008-2736-5524

Patrycja Sosnowska-SienkiewiczDepartment of Pediatric Surgery, Medical University of Warsaw, Żwirki i Wigury 63A Street, 02-091 Warsaw, Poland.ORCID 0000-0003-4714-6501

Jarosław SzydłowskiDepartment of Pediatric Otolaryngology, Poznan University of Medical Sciences, 27/33 Szpitalna Street, 60-572 Poznan, Poland.ORCID 0000-0002-8447-788X

Paweł KurzawaDepartment of Clinical Pathology, Poznan University of Medical Sciences, Przybyszewskiego 49 Street, 60-355 Poznan, Poland.

Danuta Januszkiewicz-LewandowskaDepartment of Paediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, 27/33 Szpitalna Street, 60-572 Poznan, Poland.ORCID 0000-0003-2332-2750

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conventional melanoma is exceedingly rare in the pediatric population, particularly among prepubescent children, and its diagnosis and management necessitate a multidisciplinary approach. The objective of this present report is to delineate the diagnostic pathway and therapeutic management of a 4-year-old girl with conventional melanoma, with particular focus on the molecular context. A pigmented lesion located on the auricle was surgically excised, and subsequent histopathological and immunohistochemical analyses confirmed the diagnosis of malignant melanoma (pT3b). Radiologic investigations revealed no evidence of metastatic disease, and comprehensive genetic testing utilizing next-generation sequencing (NGS) identified no pathogenic variants in the germline genes examined, nor in the

Indexed as

MelanomaSkin NeoplasmsChild, PreschoolCutaneous Malignant MelanomaFemaleGTP PhosphohydrolasesHigh-Throughput Nucleotide SequencingHumansMembrane ProteinsMutationProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)BRAF protein, humanGTP PhosphohydrolasesMembrane ProteinsNRAS protein, humanProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)childmelanomamolecular testing

Identifiers

PMID40869985

DOI10.3390/genes16080937

PMCPMC12385200

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.