Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Zeynep Erdogan-YildirimCenter for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0001-5349-6562
Jenna C CarlsonDepartment of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0001-5483-0833
Nandita MukhopadhyayCenter for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0001-7117-9536
Elizabeth J Leslie-ClarksonDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Carmencita D PadillaDepartment of Pediatrics, College of Medicine, University of the Philippines Manila, Ermita, Manila 1000, Metro Manila, Philippines.ORCID 0000-0002-5812-1871
Jeffrey C MurrayDepartment of Pediatrics, University of Iowa School of Medicine, Iowa City, IA 52242, USA.
Terri H BeatyDepartment of Epidemiology, Bloomberg School of Public Health, John Hopkins University, Baltimore, MD 21205, USA.
Seth M WeinbergCenter for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0001-9467-4556
Mary L MarazitaCenter for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0002-2648-2832
John R ShafferCenter for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0003-1897-1131
Funding
Extending the Phenotype of Nonsyndromic Orofacial CleftsR01DE016148 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARAZITA, MARY L., WEINBERG, SETH M · 2004 to 2018
$19.7M
Molecular Genetic Epidemiology of Cleft Lip and PalateR37DE008559 · NIDCR · UNIVERSITY OF IOWA · PI MURRAY, JEFFREY C · 2004 to 2013
$6.8M
Investigating the role of genes, maternal exposures, and interactions on orofacial cleftsR01DE032122 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHAFFER, JOHN R · 2022 to 2024
$2.1M
Pittsburgh Craniofacial Sciences Training ProgramT90DE030853 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHARLES SFEIR · 2022 to 2026
$1.8M
International Consortium to Identify Genes and Interactions Controlling Oral ClefU01DE018993 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI BEATY, TERRI H · 2007 to 2008
$1.6M
High-Throughput Computing for Genomics and Bioinformatics ResearchS10OD028483 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEE, ADRIAN V · 2021 to 2021
objectivesMaternal exposures are known to influence the risk of isolated cleft lip with or without cleft palate (CL/P)-a common and highly heritable birth defect with a multifactorial etiology.
methodsTo identify new risk loci, we conducted a genome-wide gene-environment interaction (GEI) analysis of CL/P with maternal smoking and vitamin use in Filipinos (
resultsWhile no genome-wide significant interactions were detected, we identified 11 suggestive GEIs with smoking and 24 with vitamin use. Several implicated loci contain biologically plausible genes. Notable interactions with smoking include loci near
conclusionsOur findings highlight the critical role of maternal exposures in identifying genes associated with structural birth defects such as CL/P and provide new paths to explore for CL/P genetics.
Indexed as
Cleft LipCleft PalateGene-Environment InteractionMaternal ExposurePrenatal Exposure Delayed EffectsAdultFemaleGenome-Wide Association StudyHumansMalePhilippinesPolymorphism, Single NucleotidePregnancySmokingcleft lip with or without cleft palategene–environment interactionmaternal exposurenon-syndromicPhilippines
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Gene-by-Environment Interactions Involving Maternal Exposures with Orofacial Cleft Risk in Filipinos. · full record | OpenQuestion