Evidence map›Paper›PMID 40869901›Full record

ArticleGenes2025

Gene-Sex Interaction in Non-Syndromic Orofacial Cleft Subtypes: A Case-Control Study Among the Vietnamese Population.

Le Kha Anh, Teruyuki Niimi, Satoshi Suzuki, Toko Hayakawa, Ken Kitagawa, Chisato Sakuma, Hideto Imura, Hisataka Kondo, Nguyen Huu Tu, Tong Minh Son and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Le Kha AnhDivision of Research and Treatment for Oral Maxillofacial Congenital Anomalies, Aichi Gakuin University, Nagoya 464-8651, Japan.ORCID 0009-0002-7872-9291
Teruyuki NiimiDivision of Research and Treatment for Oral Maxillofacial Congenital Anomalies, Aichi Gakuin University, Nagoya 464-8651, Japan.
Satoshi SuzukiDivision of Research and Treatment for Oral Maxillofacial Congenital Anomalies, Aichi Gakuin University, Nagoya 464-8651, Japan.
Toko HayakawaCleft Lip and Plate Center, Aichi Gakuin University Dental Hospital, Nagoya 464-8651, Japan.ORCID 0000-0003-4060-1356
Ken KitagawaDivision of Research and Treatment for Oral Maxillofacial Congenital Anomalies, Aichi Gakuin University, Nagoya 464-8651, Japan.
Chisato SakumaDivision of Research and Treatment for Oral Maxillofacial Congenital Anomalies, Aichi Gakuin University, Nagoya 464-8651, Japan.
Hideto ImuraDivision of Research and Treatment for Oral Maxillofacial Congenital Anomalies, Aichi Gakuin University, Nagoya 464-8651, Japan.
Hisataka KondoJunior College, Aichi Gakuin University, Nagoya 464-0037, Japan.ORCID 0000-0002-7373-9282
Nguyen Huu TuDepartment of Anesthesia-Resuscitation, Hanoi Medical University, Hanoi 10000, Vietnam.
Tong Minh SonSchool of Dentistry, Hanoi Medical University, Hanoi 10000, Vietnam.
Vo Truong Nhu NgocSchool of Dentistry, Hanoi Medical University, Hanoi 10000, Vietnam.
Tran Phuong ThaoDivision of Research and Treatment for Oral Maxillofacial Congenital Anomalies, Aichi Gakuin University, Nagoya 464-8651, Japan.
Nguyen Minh DucDivision of Research and Treatment for Oral Maxillofacial Congenital Anomalies, Aichi Gakuin University, Nagoya 464-8651, Japan.
Pham Nguyen Gia LocDivision of Research and Treatment for Oral Maxillofacial Congenital Anomalies, Aichi Gakuin University, Nagoya 464-8651, Japan.ORCID 0000-0002-4637-7108
Hiroo FurukawaDivision of Speech, Hearing, and Language, Aichi Gakuin University Dental Hospital, Nagoya 464-8651, Japan.
Nagana NatsumeDivision of Research and Treatment for Oral Maxillofacial Congenital Anomalies, Aichi Gakuin University, Nagoya 464-8651, Japan.
Nagato NatsumeDivision of Research and Treatment for Oral Maxillofacial Congenital Anomalies, Aichi Gakuin University, Nagoya 464-8651, Japan.

Funding

JSPS KAKENHI 23K09325
6 · The paper itself

Abstract

backgroundNon-syndromic orofacial clefts (NSOFCs) are one of the common congenital malformations in Vietnam, with 1.4 per 1000 live births, with notable sex differences in occurrence. This case-control study aims to investigate potential sex-specific interactions of

methodsA total of 720 participants were separated into 4 groups with a male/female ratio of 1:1 (160 individuals with cleft lip and palate (NSCLP), 160 with cleft lip only (NSCLO), 160 with cleft palate only (NSCPO), 240 healthy controls). Two single-nucleotide polymorphisms (SNPs), rs3809857 and rs227731, were genotyped by using the StepOnePlus Real-Time PCR System.

resultsThe most significant findings were found in the male NSCLO group under a recessive model of

conclusionthis study identified the critical role of

Indexed as

Carrier ProteinsCleft LipCleft PalateWnt3 ProteinCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenotypeHumansMaleNoggin ProteinPolymorphism, Single NucleotideSex FactorsSoutheast Asian PeopleVietnamCarrier ProteinsNoggin ProteinWnt3 ProteinWNT3 protein, humanNOGnon-syndromic orofacial cleftsVietnameseWNT3

Identifiers

PMID40869901
PMCPMC12385273

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.