Evidence map›Paper›PMID 40869570›Full record

ReviewJournal of clinical medicine2025

Decoding the Link Between Talcum Powder and Ovarian Cancer: A Comprehensive Review.

Sophia Tsokkou, Alkis Matsas, Ioannis Konstantinidis, Eleni Stamoula, Sofoklis Stavros, Evaggelia Karopoulou, Anastasios Potiris, Theodore Troupis

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sophia TsokkouDepartment of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0009-0000-1703-6980
Alkis MatsasLaboratory of Experimental Surgery and Surgical Research 'N.S. Christeas', Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0002-9758-8079
Ioannis KonstantinidisDepartment of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0009-0000-1632-821X
Eleni StamoulaDepartment of Clinical Pharmacology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0002-8952-821X
Sofoklis StavrosThird Department of Obstetrics and Gynecology, Medical School, "Attikon Hospital", National and Kapodistrian University of Athens, 12462 Athens, Greece.
Evaggelia KaropoulouSecond Department of Obstetrics and Gynecology, Medical School, "Aretaieion" University Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0009-0008-6215-7464
Anastasios PotirisThird Department of Obstetrics and Gynecology, Medical School, "Attikon Hospital", National and Kapodistrian University of Athens, 12462 Athens, Greece.ORCID 0000-0001-7716-1521
Theodore TroupisDepartment of Anatomy, Faculty of Health Sciences, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Str., 11627 Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian cancer (OC) is a highly lethal gynecologic malignancy, frequently diagnosed at advanced stages due to its silent onset and nonspecific clinical presentation. The use of talc-containing powders in the genital area has long been suspected to contribute to the development of OC through inflammatory and irritative pathways; however, the association remains controversial. This scoping review aims to decode the link between talc powder exposure and ovarian cancer by synthesizing findings from epidemiologic studies, public awareness surveys, and laboratory investigations. Epidemiologic analyses reveal that the use of genital powders is associated with a, modestly, 30-32% increase in the risk of OC, with similar risk patterns observed across racial subgroups. In contrast, studies on uterine cancer yield largely null associations after adjusting for confounders. Awareness surveys consistently report that only about 23% of respondents recognize talc use as a risk factor. Laboratory studies demonstrate that the dominant class of talc particles in commercially available powders-characterized by an aspect ratio of 1-3.9 and an area of 1-400 μm

Indexed as

genital powderovarian cancertalcumtalcum powder

Identifiers

PMID40869570
PMCPMC12387871

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.