Evidence map›Paper›PMID 40869462›Full record

ArticleJournal of clinical medicine2025

Defining the Chronic Complexities of hEDS and HSD: A Global Survey of Diagnostic Challenges, Life-Long Comorbidities, and Unmet Needs.

Victoria Daylor, Molly Griggs, Amy Weintraub, Rebecca Byrd, Taylor Petrucci, Matthew Huff, Kathryn Byerly, Roman Fenner, Sydney Severance, Charlotte Griggs and 14 more

Registry-linked trialAbstract read
In one paragraph

Article in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07688096 (Regenerative Medicine for Joint Hypermobility and Instability), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07688096 phase1 / phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Regenerative Medicine for Joint Hypermobility and Instability: A Prospective, Open-Label, Single-Arm, Step-Care Clinical Study

TypeinterventionalSponsorManhattan Pain Medicine, PLLCRan2026 to 2028Enrolled100ConditionsEhlers-Danlos Syndrome Hypermobility Type (hEDS), Ehlers-Danlos Syndrome (EDS), Joint Hypermobility, Joint InstabilityArmsDextrose 20% Prolotherapy, Autologous Platelet-Rich Plasma, Doxycycline Hyclate Injectable (Investigational), Visco-3 Sodium Hyaluronate Viscosupplementation
3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Victoria DaylorDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29407, USA.ORCID 0009-0002-4847-0709
Molly GriggsDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29407, USA.ORCID 0009-0003-7786-5053
Amy WeintraubDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29407, USA.ORCID 0009-0007-8409-3740
Rebecca ByrdDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29407, USA.
Taylor PetrucciDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29407, USA.ORCID 0000-0003-1524-5804
Matthew HuffDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29407, USA.ORCID 0000-0001-6760-0762
Kathryn ByerlyDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29407, USA.
Roman FennerDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29407, USA.
Sydney SeveranceDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29407, USA.
Charlotte GriggsDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29407, USA.
Amol SharmaDivision of Gastroenterology, Medical University of South Carolina, Charleston, SC 29407, USA.ORCID 0000-0002-5843-1220
Paldeep AtwalAtwal Clinic, Palm Beach, FL 33401, USA.ORCID 0000-0002-8515-744X
Steven A KautzDepartment of Health Science and Research, Medical University of South Carolina, Charlston, SC 29407, USA.ORCID 0000-0003-3151-8235
Steven ShapiroDivision of Pediatric Dentistry, Medical University of South Carolina College of Dental Medicine, Charlston, SC 29407, USA.
Kimberly YoukhanaDivision of Hematology and Oncology, Medical University of South Carolina, Charlston, SC 29407, USA.
Mark LavalleeDepartment of Orthopedics and Sports Medicine, UPMC-Central PA, Harrisburg, PA 17109, USA.
Allison WilkersonDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charlston, SC 29407, USA.
Michelle NicholsDepartment of Health Science and Research, Medical University of South Carolina, Charlston, SC 29407, USA.ORCID 0000-0002-2078-9649
Alan SnyderDepartment of Dermatology, Medical University of South Carolina, Charlston, SC 29407, USA.ORCID 0000-0001-9115-626X
Josef K EichingerDepartment of Orthopedic Surgery and Physical Medicine, Medical University of South Carolina, Charlston, SC 29407, USA.ORCID 0000-0001-8563-7307
Sunil PatelDepartment of Neurosurgery, Medical University of South Carolina, Charleston, SC 29407, USA.
Anne MaitlandDivision of Rheumatology and Immunology, Medical University of South Carolina, Charlston, SC 29407, USA.
Cortney GensemerDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29407, USA.ORCID 0000-0002-8492-3536
Russell A NorrisDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29407, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

chronic conditionsEhlers–Danlos syndromehypermobility

Identifiers

PMID40869462
PMCPMC12386360

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.