Evidence map›Paper›PMID 40869389›Full record

ArticleInternational journal of molecular sciences2025

Evaluation of Selected Serum Adipocytokines in Patients with Relapsing-Remitting Multiple Sclerosis Treated with Immunomodulatory Second-Line Drugs.

Bożena Adamczyk, Natalia Morawiec, Robert Kwinta, Michał Rakoca, Sławomir Wawrzyniak, Jolanta Zalejska-Fiolka, Agata Sowa, Ksawier Sawa, Monika Adamczyk-Sowa

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Is Obesity a Modifiable Risk Factor in Multiple Sclerosis? Mechanistic Insights into Neuroinflammation and Oxidative Damage.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bożena AdamczykDepartment of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 41-800 Zabrze, Poland.ORCID 0000-0003-1641-5350
Natalia MorawiecDepartment of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 41-800 Zabrze, Poland.ORCID 0000-0003-4859-3880
Robert KwintaDepartment of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 41-800 Zabrze, Poland.ORCID 0000-0003-4506-3737
Michał RakocaDepartment of Neurology, 10th Military Research Hospital and Polyclinic, 85-681 Bydgoszcz, Poland.
Sławomir WawrzyniakDepartment of Neurology, 10th Military Research Hospital and Polyclinic, 85-681 Bydgoszcz, Poland.
Jolanta Zalejska-FiolkaDepartment of Biochemistry, Faculty of Medical Science in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.ORCID 0000-0002-3879-6548
Agata SowaDepartment of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 41-800 Zabrze, Poland.
Ksawier SawaDepartment of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 41-800 Zabrze, Poland.
Monika Adamczyk-SowaDepartment of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 41-800 Zabrze, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adipocytokines are involved in the pathogenesis of multiple sclerosis by modulating inflammation, blood-brain barrier function and immune responses, which may affect disease course and treatment outcomes. Our study assessed serum levels of visfatin, adiponectin and resistin in patients with relapsing-remitting multiple sclerosis treated with fingolimod or natalizumab. We examined 49 patients with relapsing-remitting multiple sclerosis and 38 healthy controls. Participants were divided into three groups: patients treated with fingolimod, those treated with natalizumab and the controls. Serum levels of visfatin, adiponectin and resistin were measured. We analyzed correlations with disease duration, treatment duration and body mass index. Adiponectin levels were significantly higher in patients treated with natalizumab compared to those receiving fingolimod and healthy controls (

Indexed as

AdipokinesFingolimod HydrochlorideMultiple Sclerosis, Relapsing-RemittingAdiponectinAdultBody Mass IndexCase-Control StudiesFemaleHumansMaleMiddle AgedNatalizumabNicotinamide PhosphoribosyltransferaseResistinAdipokinesAdiponectinFingolimod HydrochlorideNatalizumabNicotinamide PhosphoribosyltransferaseResistinadipocytokinesadiponectinfingolimodmultiple sclerosisnatalizumabresistinvisfatin

Identifiers

PMID40869389
PMCPMC12387034

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.