Evidence map›Paper›PMID 40869363›Full record

SynthesisInternational journal of molecular sciences2025

Vacuolated Marrow Cytopenias from Copper Deficiency to

Akiyoshi Takami, Kaori Uchino, Mai Terashima, Seiko Sato, Yuka Kondo, J Luis Espinoza, Megumi Enomoto

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. VEXAS syndrome.Nature reviews. Disease primers · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Akiyoshi TakamiDivision of Hematology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute 480-1195, Japan.ORCID 0000-0002-1822-9976
Kaori UchinoDivision of Hematology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute 480-1195, Japan.ORCID 0000-0003-2983-2129
Mai TerashimaDepartment of Central Clinical Laboratory, Aichi Medical University Hospital, Nagakute 480-1195, Japan.
Seiko SatoDepartment of Clinical Laboratory, Fujita Health University Hospital, Toyoake 470-1192, Japan.
Yuka KondoDepartment of Central Clinical Laboratory, Toyohashi Municipal Hospital, Toyohashi 441-8570, Japan.
J Luis EspinozaFaculty of Health Sciences, Kanazawa University, Kanazawa 920-0942, Japan.ORCID 0000-0002-1794-6666
Megumi EnomotoDepartment of Central Clinical Laboratory, Aichi Medical University Hospital, Nagakute 480-1195, Japan.

Funding

The Ministry of Education, Culture, Sports, Science and Technology of Japan KAKENHI 24K11527The Ministry of Health, Labour and Welfare of Japan 23KC2009
6 · The paper itself

Abstract

Although cytoplasmic vacuoles are instantly recognizable on bone marrow smears, their etiologic significance remains a diagnostic dilemma in everyday practice. We conducted a PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) aligned systematic review with narrative synthesis registered in PROSPERO and refrained from meta-analysis owing to high between-study heterogeneity (I

Indexed as

Bone MarrowCopperMutationUbiquitin-Activating EnzymesAlgorithmsCost-Benefit AnalysisCytopeniaHumansMyelodysplastic SyndromesSkin Diseases, GeneticCopperUBA1 protein, humanUbiquitin-Activating Enzymescopper deficiencycytopeniadiagnostic algorithmsystematic reviewUBA1vacuolesVEXAS

Identifiers

PMID40869363
PMCPMC12386339

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.