Evidence map›Paper›PMID 40869359›Full record

ArticleInternational journal of molecular sciences2025

MiRNA-186 as a Biomarker of Disease Exacerbation in Rheumatoid Arthritis: Insights from Clinical Data and Molecular Marker Analysis.

Marek Cieśla, Dorota Darmochwał-Kolarz, Hubert Kubis, Bogdan Kolarz

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Marek CieślaLaboratory of Diagnostic and Clinical Epigenetics, Faculty of Medicine, University of Rzeszow, 35-310 Rzeszow, Poland.ORCID 0000-0002-9758-078X
Dorota Darmochwał-KolarzDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Rzeszow, 35-310 Rzeszow, Poland.ORCID 0000-0002-1590-442X
Hubert KubisLaboratory of Diagnostic and Clinical Epigenetics, Faculty of Medicine, University of Rzeszow, 35-310 Rzeszow, Poland.ORCID 0009-0002-7309-1233
Bogdan KolarzDepartment of Rheumatology, Faculty of Medicine, University of Rzeszow, 35-310 Rzeszow, Poland.ORCID 0000-0001-8496-6846

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease characterized by inflammation of the synovial tissue, leading to joint destruction, pain, stiffness, and progressive impairment of motor functions. Despite significant advances in diagnosis and treatment, RA remains a major clinical and social challenge, negatively impacting patients' quality of life. The aim of this study was to assess the relationship between the expression of selected microRNAs (miRNAs) and the activity of the disease. A total of 46 RA patients and 20 healthy controls (HCs) were enrolled in the study. A quantitative real-time polymerase chain reaction was used to evaluate the expression of miRNAs in whole blood. MiRNA-186 exhibited decreased concentrations in RA patients compared to HCs (

Indexed as

Arthritis, RheumatoidBiomarkersMicroRNAsAdultAgedBlood SedimentationCase-Control StudiesDisease ProgressionFemaleHumansMaleMiddle AgedBiomarkersMicroRNAsMIRN186 microRNA, humanDAS28disease activitymicroRNAmiR-186noncoding RNArheumatoid arthritis

Identifiers

PMID40869359
PMCPMC12386512

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.