ArticleInternational journal of molecular sciences2025
Vitamin D as an Epigenetic Regulator: A Hypothetical Mechanism for Cancer Prevention via Inhibition of Oncogenic lncRNA HOTAIR.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Vitamin D in Gut and Systemic Immune Tolerance and in Infections' Risk: An International Evidence-Based Consensus Statement.Reviews in endocrine & metabolic disorders · 2026Review
- Synthetic Modulators of the Vitamin D Receptor: From Structural Innovation to Disease-Specific Applications.Biomolecules · 2026Review
- Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer remains a leading cause of mortality worldwide, arising from a complex interplay of genetic, epigenetic, and environmental factors. Although the role of micronutrients in cancer development has received limited attention, growing evidence suggests that vitamins, particularly vitamin D, may influence oncogenic pathways. This hypothesis manuscript explores the potential interaction between vitamin D and the oncogenic long non-coding RNA HOTAIR, providing a novel mechanistic explanation for the inverse correlation between vitamin D status and cancer risk. We support our hypothesis with in silico docking evidence, suggesting that vitamin D binds to bioactive domains within the structured regions of HOTAIR, potentially disrupting its interaction with chromatin regulators such as PRC2. This concept may offer a novel approach to cancer prevention and therapy.
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Registered trials
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