ArticleInternational journal of molecular sciences2025
Polymorphic Variants of Neurotrophic Factor Genes in Affective Disorders: Pilot Study.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Neurotrophic factors are regulatory proteins of nervous tissue. They have a significant effect on all processes in neurons. Neurotrophic factors participate in the processes of neuronal differentiation, neurogenesis, synaptogenesis, and the regulation of neuronal plasticity. Numerous data in the literature indicate that disruption of the regulation of neurotrophic factors can play an important role in the etiology of affective disorders. We examined 235 patients with an affective disorder (F31, F32, F33, F34.1, ICD-10) and 187 healthy controls. The mental state of the patients was assessed by SIGH-SAD, HARS, and CGI scales. Genotyping of polymorphic variants of neurotrophic factor genes (
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