Reproductive Risk Assessment of Bisphenol A and Its Substitutes on Estrogen Receptors (ERs) in Bivalves.

Weili Guo, Pengyu Zhang, Jianyong Song, Chunnuan Zhang, Ruiyi Xu

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Molecular Cloning and Characterization of Estrogen-Related Receptor Gene inBiology · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Weili GuoThe Water Environment and Animal Safety Laboratory, Henan University of Science and Technology, Luoyang 471000, China.

Pengyu ZhangThe Water Environment and Animal Safety Laboratory, Henan University of Science and Technology, Luoyang 471000, China.

Jianyong SongThe Water Environment and Animal Safety Laboratory, Henan University of Science and Technology, Luoyang 471000, China.

Chunnuan ZhangThe Water Environment and Animal Safety Laboratory, Henan University of Science and Technology, Luoyang 471000, China.

Ruiyi XuThe Water Environment and Animal Safety Laboratory, Henan University of Science and Technology, Luoyang 471000, China.

Funding

National Natural Science Foundation of China 42207331

6 · The paper itself

Abstract

As benthic filter feeders, bivalve mollusks serve as ideal biological indicators. Bisphenol A (BPA) and its substitutes (BPS, BPF, and BPAF) are endocrine disruptors with reproductive toxicity, targeting estrogen receptors (ERs). However, their binding sites and affinity for shellfish ERs remain unclear. This study aims to identify ER binding sites of BPA and its substitutes, compare toxicity via molecular docking, and validate results through exposure experiments. The full-length cDNA of

Indexed as

Benzhydryl CompoundsBivalviaEndocrine DisruptorsPhenolsReceptors, EstrogenReproductionAmino Acid SequenceAnimalsBinding SitesBisphenol A CompoundsBisphenol F CompoundsMolecular Docking SimulationRisk AssessmentWater Pollutants, ChemicalBenzhydryl Compoundsbisphenol ABisphenol A Compoundsbisphenol FBisphenol F CompoundsEndocrine DisruptorsPhenolsReceptors, EstrogenWater Pollutants, Chemicalbisphenol A and its substitutesbivalvesestrogen receptorshomology modeltoxicity

Identifiers

PMID40869290

DOI10.3390/ijms26167969

PMCPMC12387002

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.