Evidence map›Paper›PMID 40869287›Full record

ArticleInternational journal of molecular sciences2025

Differential Sensitivity of Hippocampal GABAergic Neurons to Hypoxia and Ischemia-like Conditions Correlates with the Type of Calcium-Binding Protein Expressed.

Maria V Turovskaya, Valery P Zinchenko

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Pathophysiology and Prognostic Significance of Myoclonus in Hypoxic-Ischemic Encephalopathy.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2026
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Maria V TurovskayaInstitute of Cell Biophysics of the Russian Academy of Sciences, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", 142290 Pushchino, Russia.
Valery P ZinchenkoInstitute of Cell Biophysics of the Russian Academy of Sciences, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", 142290 Pushchino, Russia.ORCID 0000-0002-1990-3803

Funding

the State assignment of PSCBR RAS 075-00607-25-00
6 · The paper itself

Abstract

Using in vitro models of hypoxia, episodes of short-term hypoxia/reoxygenation, and ischemia-like conditions, we were able to establish different sensitivities of hippocampal neurons to their damaging factors. Using a combination of fluorescence microscopy and immunocytochemistry methods, it was possible to show that GABAergic neurons are the most vulnerable to the damaging effects of hypoxia and ischemia-like conditions, as they have a special metabolism, which is characterized by increased production of reactive oxygen species and nitric oxide. It was shown that long-term hypoxia causes the death of GABAergic neurons due to the induction of a global [Ca

Indexed as

Calcium-Binding ProteinsGABAergic NeuronsHippocampusHypoxiaIschemiaAnimalsCalciumCell HypoxiaCells, CulturedNitric OxideParvalbuminsPyramidal CellsRatsRats, WistarReactive Oxygen SpeciesCalciumCalcium-Binding ProteinsNitric OxideParvalbuminsReactive Oxygen Speciescalcium-binding proteinscalcium signalingglutamate receptorshypoxiahypoxic preconditioningischemianeuronal death

Identifiers

PMID40869287
PMCPMC12386940

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.