Evidence map›Paper›PMID 40869266›Full record

ArticleInternational journal of molecular sciences2025

Novel Carbazole-Thiazole Conjugates: Synthesis and Biophysical Characterization.

Beata Donarska, Klaudia Seklecka, Joanna Cytarska, Katarzyna Piechowska, Przemyslaw Ledwon, Sławomir Kula, Przemysław Krawczyk, Angelika Baranowska-Łączkowska, Krzysztof Z Łączkowski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Beata DonarskaDepartment of Chemical Technology and Pharmaceuticals, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, Jurasza 2, 85-089 Bydgoszcz, Poland.ORCID 0000-0003-4055-3788
Klaudia SekleckaDepartment of Chemical Technology and Pharmaceuticals, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, Jurasza 2, 85-089 Bydgoszcz, Poland.
Joanna CytarskaDepartment of Chemical Technology and Pharmaceuticals, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, Jurasza 2, 85-089 Bydgoszcz, Poland.ORCID 0000-0002-5313-6812
Katarzyna PiechowskaDepartment of Chemical Technology and Pharmaceuticals, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, Jurasza 2, 85-089 Bydgoszcz, Poland.ORCID 0000-0002-5655-5393
Przemyslaw LedwonDepartment of Physical Chemistry and Technology of Polymers, Faculty of Chemistry, Silesian University of Technology, Strzody 9, 44-100 Gliwice, Poland.ORCID 0000-0001-6769-8739
Sławomir KulaInstitute of Chemistry, Faculty of Science and Technology, University of Silesia, Szkolna 9 St., 40-007 Katowice, Poland.ORCID 0000-0003-4520-1570
Przemysław KrawczykDepartment of Physical Chemistry, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, Kurpińskiego 5, 85-950 Bydgoszcz, Poland.ORCID 0000-0002-3387-2820
Angelika Baranowska-ŁączkowskaFaculty of Physics, Kazimierz Wielki University, Powstańców Wielkopolskich 2, 85-090 Bydgoszcz, Poland.ORCID 0000-0001-9285-4991
Krzysztof Z ŁączkowskiDepartment of Chemical Technology and Pharmaceuticals, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, Jurasza 2, 85-089 Bydgoszcz, Poland.ORCID 0000-0003-2107-2719

Funding

Nicolaus Copernicus University WF 540/2020Wroclaw Centre for Networking and Supercomputing grant No 585
6 · The paper itself

Abstract

This presented study depicts the synthesis of three novel carbazole-thiazole conjugates, thoroughly investigating their spectroscopic properties as well as evaluating their biological activity as tyrosinase inhibitors. Additionally, we investigated the possibility of using Concanavalin A (ConA) complexes with dyes from a theoretical point of view, developing a promising protein-based strategy of delivery of dyes to the target cells. The tyrosinase inhibition assay showed that compounds

Indexed as

CarbazolesEnzyme InhibitorsThiazolesConcanavalin AMolecular Docking SimulationMonophenol MonooxygenasecarbazoleCarbazolesConcanavalin AEnzyme InhibitorsMonophenol MonooxygenaseThiazolescarbazolecyclic voltammetryoptical materialsphotoluminescenceTD-DFT methodthermogravimetric analysisthiazoletyrosinase

Identifiers

PMID40869266
PMCPMC12386811

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.