Evidence map›Paper›PMID 40869263›Full record

ArticleInternational journal of molecular sciences2025

Prime Editing Modification with FEN1 Improves F508del Variant Editing in the

Olga V Volodina, Anna G Demchenko, Arina A Anuchina, Oxana P Ryzhkova, Valeriia A Kovalskaya, Ekaterina V Kondrateva, Ekaterina V Artemova, Vyacheslav Y Tabakov, Maxim A Ignatov, Natalia Y Vorobyeva and 3 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Olga V VolodinaLaboratory of Genome Editing, Research Centre for Medical Genetics, 115522 Moscow, Russia.ORCID 0000-0001-7086-2288
Anna G DemchenkoLaboratory of Genome Editing, Research Centre for Medical Genetics, 115522 Moscow, Russia.ORCID 0000-0002-4460-7627
Arina A AnuchinaLaboratory of Genome Editing, Research Centre for Medical Genetics, 115522 Moscow, Russia.ORCID 0000-0003-1820-5461
Oxana P RyzhkovaThe Shared Resource Centre "Genome", Research Centre for Medical Genetics, 115522 Moscow, Russia.ORCID 0000-0003-1285-9093
Valeriia A KovalskayaThe Shared Resource Centre "Genome", Research Centre for Medical Genetics, 115522 Moscow, Russia.ORCID 0000-0002-8728-8574
Ekaterina V KondratevaLaboratory of Genome Editing, Research Centre for Medical Genetics, 115522 Moscow, Russia.ORCID 0000-0003-0770-2569
Ekaterina V ArtemovaLaboratory of Genome Editing, Research Centre for Medical Genetics, 115522 Moscow, Russia.ORCID 0009-0001-0997-9257
Vyacheslav Y TabakovThe Shared Resource Centre "Biobank", Research Centre for Medical Genetics, 115522 Moscow, Russia.ORCID 0000-0003-0291-153X
Maxim A IgnatovLaboratory of Radiation Biophysics, Department of Experimental Radiobiology and Radiation Medicine, State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency (SRC-FMBC), 123098 Moscow, Russia.ORCID 0000-0003-0381-5267
Natalia Y VorobyevaLaboratory of Radiation Biophysics, Department of Experimental Radiobiology and Radiation Medicine, State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency (SRC-FMBC), 123098 Moscow, Russia.ORCID 0000-0001-9008-4401
Andreyan N OsipovLaboratory of Radiation Biophysics, Department of Experimental Radiobiology and Radiation Medicine, State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency (SRC-FMBC), 123098 Moscow, Russia.ORCID 0000-0001-5921-9056
Alexander V LavrovLaboratory of Genome Editing, Research Centre for Medical Genetics, 115522 Moscow, Russia.ORCID 0000-0003-4962-6947
Svetlana A SmirnikhinaLaboratory of Genome Editing, Research Centre for Medical Genetics, 115522 Moscow, Russia.ORCID 0000-0002-1558-3048

Funding

The Ministry of Science and Higher Education of the Russian Federation for RCMG N/A
6 · The paper itself

Abstract

Prime editing is a promising approach for correcting pathogenic variants, but its efficiency remains variable across genomic contexts. Here, we systematically evaluated 12 modifications of the PEmax system for correcting the

Indexed as

Cystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorFlap EndonucleasesGene EditingCRISPR-Cas SystemsExodeoxyribonucleasesHumansCFTR protein, humanCystic Fibrosis Transmembrane Conductance RegulatorExodeoxyribonucleasesFlap Endonucleasescystic fibrosisEXO1FEN1gene editinggene therapyprime editing

Identifiers

PMID40869263
PMCPMC12386499

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.