Evidence map›Paper›PMID 40869254›Full record

ArticleInternational journal of molecular sciences2025

The Impact of Bariatric Surgery on Gut Microbiota Composition and Diversity: A Longitudinal Analysis Using 16S rRNA Sequencing.

Radu Petru Soroceanu, Daniel Vasile Timofte, Sergiu Timofeiov, Vlad Ionut Vlasceanu, Madalina Maxim, Ancuta Andreea Miler, Andi Gabriel Iordache, Roxana Moscalu, Mihaela Moscalu, Irina Cezara Văcărean-Trandafir and 3 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Radu Petru SoroceanuDepartment of Surgery, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.
Daniel Vasile TimofteDepartment of Surgery, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.
Sergiu TimofeiovDepartment of Surgery, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.
Vlad Ionut VlasceanuDepartment of Surgery, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.
Madalina MaximDepartment of Surgery, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.
Ancuta Andreea MilerDepartment of Surgery, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.
Andi Gabriel IordacheDepartment of Surgery, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.
Roxana MoscaluDivision of Cell Matrix Biology & Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PL, UK.ORCID 0000-0002-3450-7200
Mihaela MoscaluDepartment of Preventive Medicine and Interdisciplinarity, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0000-0002-8899-8594
Irina Cezara Văcărean-TrandafirTRANSCEND Research Center for Fundamental and Experimental Development in Translational Medicine, Regional Institute of Oncology, 700483 Iaşi, Romania.ORCID 0000-0002-7329-5431
Roxana-Maria AmărandiTRANSCEND Research Center for Fundamental and Experimental Development in Translational Medicine, Regional Institute of Oncology, 700483 Iaşi, Romania.ORCID 0000-0002-9937-6539
Iuliu Cristian IvanovTRANSCEND Research Center for Fundamental and Experimental Development in Translational Medicine, Regional Institute of Oncology, 700483 Iaşi, Romania.ORCID 0000-0001-5372-9901
Alin Constantin PînzariuDepartment of Surgery, "Sf. Spiridon" County Clinical Emergency Hospital, 700111 Iași, Romania.ORCID 0000-0001-5730-1662

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bariatric surgery is considered the most effective treatment for obesity and its associated metabolic disorders, yet the underlying mechanisms are only partially understood. Evidence suggests that the gut microbiota plays an important role in metabolic regulation and can be significantly altered by bariatric and metabolic procedures. This prospective, single-center study aimed to evaluate the dynamic changes in the gut microbiota composition and diversity in obese patients undergoing two types of bariatric surgery: laparoscopic sleeve gastrectomy (LSG) and Roux-en-Y gastric bypass (RYGB). Fecal samples were collected at three time points-before surgery (T0), and at 3 (T3) and 6 months (T6) postoperatively-and analyzed using 16S rRNA gene sequencing targeting the V3-V4 regions with Illumina technology. Significant shifts in microbial diversity and structure were observed over time, indicating a trend toward microbiota normalization post-surgery. Notable changes included a reduction in the

Indexed as

Bariatric SurgeryGastrointestinal MicrobiomeRNA, Ribosomal, 16SAdultBacteriaBiodiversityBody Mass IndexFecesFemaleGastrectomyGastric BypassHumansLongitudinal StudiesMaleMiddle AgedObesityRNA, Ribosomal, 16S16S rRNAbariatric surgerygut microbiotaLSGmetabolic healthmicrobial diversityobesityRYGB

Identifiers

PMID40869254
PMCPMC12386285

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.