Evidence map›Paper›PMID 40869250›Full record

ArticleInternational journal of molecular sciences2025

César A Valdez-Gaxiola, Frida Rosales-Leycegui, Abigail Gaxiola-Rubio, Sofía Dumois-Petersen, Martha Patricia Gallegos-Arreola, John M Ringman, Luis E Figuera

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

César A Valdez-GaxiolaDivisión de Genética, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara 44340, Jalisco, Mexico.ORCID 0009-0009-6100-093X
Frida Rosales-LeyceguiDivisión de Genética, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara 44340, Jalisco, Mexico.ORCID 0009-0005-8172-2420
Abigail Gaxiola-RubioFacultad de Medicina, Universidad Autónoma de Guadalajara, Zapopan 45129, Jalisco, Mexico.ORCID 0009-0000-1011-7155
Sofía Dumois-PetersenLaboratorio de Ciencias Clínicas, CuValles, Universidad de Guadalajara, Ameca 46600, Jalisco, Mexico.ORCID 0009-0003-5858-8978
Martha Patricia Gallegos-ArreolaDivisión de Genética, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0003-4539-1693
John M RingmanAlzheimer Disease Research Center, Department of Neurology, Keck School of Medicine at USC, 1520 San Pablo Street Suite 3000, Los Angeles, CA 90033, USA.
Luis E FigueraDivisión de Genética, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara 44340, Jalisco, Mexico.ORCID 0000-0002-6096-4579

Funding

USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI · 2020 to 2026
$27.8M
Phenotype and Genotype of Autosomal Dominant Alzheimer's Disease in Jalisco, MexicoR01AG069013 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI RINGMAN, JOHN M · 2020 to 2024
$3.3M
Fundación IMSS R-2022-1305-100National Institutes of Health/Fogarty 1R01AG069013-01NIA NIH HHS P30 AG066530NIA NIH HHS R01 AG069013
6 · The paper itself

Abstract

While most of the Alzheimer's disease (AD) cases are sporadic and manifest after age 65 (late-onset AD, LOAD), a subset of patients develop symptoms earlier in life (early-onset, EOAD) due to mutations in the

Indexed as

Alzheimer DiseaseApolipoprotein E4Carrier ProteinsPresenilin-1AgedAge of OnsetFemaleGenotypeHumansMaleMiddle AgedMutationApolipoprotein E4Carrier ProteinsPresenilin-1PSEN1 protein, humanage of onsetAPOEautosomal-dominant Alzheimer’s diseaseearly-onset Alzheimer’s disease

Identifiers

PMID40869250
PMCPMC12387094

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.