Evidence map›Paper›PMID 40869231›Full record

ArticleInternational journal of molecular sciences2025

Sourat Darabi, Phillip Stafford, David R Braxton, Carlos E Zuazo, Taylor J Brodie, Michael J Demeure

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sourat DarabiHoag Family Cancer Institute, Newport Beach, CA 92663, USA.ORCID 0000-0002-3395-894X
Phillip StaffordHoag Family Cancer Institute, Newport Beach, CA 92663, USA.ORCID 0000-0001-7989-9036
David R BraxtonHoag Family Cancer Institute, Newport Beach, CA 92663, USA.
Carlos E ZuazoHoag Family Cancer Institute, Newport Beach, CA 92663, USA.ORCID 0000-0003-1608-3683
Taylor J BrodieHoag Family Cancer Institute, Newport Beach, CA 92663, USA.
Michael J DemeureHoag Family Cancer Institute, Newport Beach, CA 92663, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BRAF inhibitors have a 50-70% response rate in melanoma but are less effective for thyroid cancer. Differential response may be from activation or expression of downstream mitogen-activated protein kinase (MAPK) pathway genes. Retrospective analysis compared whole exome and transcriptome sequencing in melanoma and thyroid cancers from April 2019 to October 2023. The MAPK Activation Score (MPAS) was calculated using Z-score normalized/log-transformed values indicating expression across 10 MAPK-associated genes. Our tumor registry provided outcome data.

Indexed as

Gene Expression Regulation, NeoplasticMAP Kinase Signaling SystemMelanomaMutationProto-Oncogene Proteins B-rafThyroid NeoplasmsAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedRetrospective StudiesBRAF protein, humanProto-Oncogene Proteins B-rafBRAF mutationsmelanomaRNA expressionthyroid cancerwhole exome sequencingwhole transcriptome sequencing

Identifiers

PMID40869231
PMCPMC12386775

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.