Partial eNOS Deficiency Results in Greater Levels of Vascular Inflammation and BBB Disruption in Response to Chronic Mild Hypoxia.

Arjun Sapkota, Sebok K Halder, Saifudeen Ismael, Gregory J Bix, Richard Milner

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Arjun SapkotaSan Diego Biomedical Research Institute, 3525 John Hopkins Court, Suite 200, San Diego, CA 92121, USA.

Sebok K HalderSan Diego Biomedical Research Institute, 3525 John Hopkins Court, Suite 200, San Diego, CA 92121, USA.ORCID 0000-0001-9472-3864

Saifudeen IsmaelDepartment of Neurosurgery, Clinical Neuroscience Research Center, School of Medicine, Tulane University, New Orleans, LA 70112, USA.ORCID 0000-0001-9976-0939

Gregory J BixDepartment of Neurosurgery, Clinical Neuroscience Research Center, School of Medicine, Tulane University, New Orleans, LA 70112, USA.ORCID 0000-0002-8969-9553

Richard MilnerSan Diego Biomedical Research Institute, 3525 John Hopkins Court, Suite 200, San Diego, CA 92121, USA.

Funding

Investigating the Role and the therapeutic potential of Perlecan in experimental vascular dementiaRF1NS136861 · NINDS · TULANE UNIVERSITY OF LOUISIANA · PI BIX, GREGORY JAYE, MILNER, D. RICHARD · 2024 to 2024

$2.6M

NIH NINDS and NIA NIH RF1 grant NS136861NINDS NIH HHS RF1 NS136861

6 · The paper itself

Abstract

Blood-brain barrier (BBB) deterioration with increasing age is an important factor contributing to vascular dementia. Previous studies show that endothelial nitric oxide synthase (eNOS) facilitates vascular endothelial growth factor-mediated angiogenesis and increased vascular permeability. In contrast, recent work has shown that aged hemi-deficient hemizygous eNOS

Indexed as

Blood-Brain BarrierHypoxiaInflammationNitric Oxide Synthase Type IIIAnimalsBrainEndothelial CellsMaleMiceMice, Inbred C57BLMice, KnockoutMicrogliaNitric Oxide Synthase Type IIINos3 protein, mouseagingblood–brain barrier (BBB) integrityblood vesselsbrainchronic mild hypoxiaendothelial nitric oxide synthase (eNOS)microglia

Identifiers

PMID40869224

DOI10.3390/ijms26167902

PMCPMC12386576

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.