Evidence map›Paper›PMID 40869212›Full record

ArticleInternational journal of molecular sciences2025

Circulating microRNAs as Early Biomarkers of Colon Cancer: A Nested Case-Control Study Within a Prospective Cohort.

Lisa Padroni, Giorgia Marmiroli, Laura De Marco, Valentina Fiano, Lucia Dansero, Saverio Caini, Giovanna Masala, Luca Manfredi, Lorenzo Milani, Fulvio Ricceri and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lisa PadroniDepartment of Clinical and Biological Sciences, Centre for Biostatistics, Epidemiology, and Public Health (C-BEPH), University of Turin, 10043 Turin, Italy.ORCID 0009-0008-9609-3681
Giorgia MarmiroliUnit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, 10126 Turin, Italy.
Laura De MarcoUnit of Cancer Epidemiology, Città Della Salute e Della Scienza University-Hospital and Center for Cancer Prevention (CPO), Via Santena 7, 10126 Turin, Italy.ORCID 0000-0003-2167-9270
Valentina FianoUnit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, 10126 Turin, Italy.
Lucia DanseroDepartment of Clinical and Biological Sciences, Centre for Biostatistics, Epidemiology, and Public Health (C-BEPH), University of Turin, 10043 Turin, Italy.ORCID 0000-0003-2304-5378
Saverio CainiCancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), 50139 Florence, Italy.ORCID 0000-0002-2262-1102
Giovanna MasalaClinical Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), 50139 Florence, Italy.ORCID 0000-0002-5758-9069
Luca ManfrediDepartment of Clinical and Biological Sciences, Centre for Biostatistics, Epidemiology, and Public Health (C-BEPH), University of Turin, 10043 Turin, Italy.ORCID 0000-0002-6530-4326
Lorenzo MilaniDepartment of Clinical and Biological Sciences, Centre for Biostatistics, Epidemiology, and Public Health (C-BEPH), University of Turin, 10043 Turin, Italy.ORCID 0000-0002-2185-2179
Fulvio RicceriDepartment of Clinical and Biological Sciences, Centre for Biostatistics, Epidemiology, and Public Health (C-BEPH), University of Turin, 10043 Turin, Italy.ORCID 0000-0001-8749-9737
Carlotta SacerdoteDepartment of Health Sciences, University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, Italy.

Funding

Governo Italiano RF 2018 12366921
6 · The paper itself

Abstract

Circulating microRNAs (miRNAs) have emerged as non-invasive biomarkers that may be associated with cancer risk, but their role in the development of colon cancer is still not well understood. We conducted a nested case-control study within the EPIC-Italy cohort to investigate the association between pre-diagnostic serum levels of eight candidate miRNAs (Let7, Mir21, Mir155, Mir181, Mir222, Mir145, Mir92, and Mir20) and subsequent colon cancer occurrence. A total of 104 incident colon cancer cases were matched to 104 controls by center, sex, age, recruitment date, and vital status. miRNA expression was quantified using RT-qPCR and normalized to Mir484. Logistic regression models were applied to estimate odds ratios, 95% confidence intervals, and

Indexed as

Biomarkers, TumorCirculating MicroRNAColonic NeoplasmsMicroRNAsAgedCase-Control StudiesFemaleHumansMaleMiddle AgedProspective StudiesRisk FactorsBiomarkers, TumorCirculating MicroRNAMicroRNAscolon cancermicroRNAnested case-control study

Identifiers

PMID40869212
PMCPMC12386545

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.