Evidence map›Paper›PMID 40869178›Full record

ArticleInternational journal of molecular sciences2025

Loss of Myh11 K1256 Dysregulates the Extracellular Matrix and Focal Adhesion by Inhibiting Zyxin-Activated Transcription.

Shota Tomida, Hironori Okuhata, Tamaki Ishima, Ryozo Nagai, Kenichi Aizawa

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shota TomidaDepartment of Translational Research, Clinical Research Center, Jichi Medical University Hospital, Tochigi 329-0498, Japan.
Hironori OkuhataDepartment of Translational Research, Clinical Research Center, Jichi Medical University Hospital, Tochigi 329-0498, Japan.
Tamaki IshimaDepartment of Translational Research, Clinical Research Center, Jichi Medical University Hospital, Tochigi 329-0498, Japan.ORCID 0009-0002-2309-265X
Ryozo NagaiJichi Medical University, Tochigi 329-0498, Japan.
Kenichi AizawaDepartment of Translational Research, Clinical Research Center, Jichi Medical University Hospital, Tochigi 329-0498, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathogenic variants of MYH11, which encode smooth muscle myosin heavy chain 11, have been linked to familial thoracic aortic aneurysms and dissections (FTAAD). However, molecular pathways affected by these mutations have not been well understood. To explore downstream consequences of Myh11 disruption, we analyzed transcriptomic and proteomic profiles of aortas from male Myh11 mice with homozygous deletion of lysine 1256 (K1256) and of wild-type controls. Of 6499 proteins quantified, 1763 were differentially expressed (adjusted

Indexed as

Extracellular MatrixMyosin Heavy ChainsTranscription, GeneticAnimalsAortaAortic Aneurysm, ThoracicAortic DissectionHumansMaleMicemyosin 11, mouseMyosin Heavy Chainsaortic dissectionMyh11proteomics

Identifiers

PMID40869178
PMCPMC12386218

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.