Evidence map›Paper›PMID 40869177›Full record

ArticleInternational journal of molecular sciences2025

The Traits of the Regenerative Potential of Platelet-Rich Plasma from Donors with Type 1 and Type 2 Diabetes Mellitus.

Tatyana I Vlasova, Ekaterina P Brodovskaya, Konstantin S Madonov, Darya A Kapitanova, Anna P Abelova, Elena N Kovalenko, Alina E Markina, Sergey I Pinyaev, Olga V Minaeva, Aleksey P Vlasov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tatyana I VlasovaFederal State Budgetary Educational Institution of Higher Education, National Research Ogarev Mordovia State University, Mordovia 430005, Russia.ORCID 0000-0002-2624-6450
Ekaterina P BrodovskayaFederal State Budgetary Educational Institution of Higher Education, National Research Ogarev Mordovia State University, Mordovia 430005, Russia.ORCID 0009-0000-5145-1029
Konstantin S MadonovFederal State Budgetary Educational Institution of Higher Education, National Research Ogarev Mordovia State University, Mordovia 430005, Russia.ORCID 0000-0002-3709-1458
Darya A KapitanovaFederal State Budgetary Educational Institution of Higher Education, National Research Ogarev Mordovia State University, Mordovia 430005, Russia.ORCID 0009-0002-1934-4463
Anna P AbelovaFederal State Budgetary Educational Institution of Higher Education, National Research Ogarev Mordovia State University, Mordovia 430005, Russia.ORCID 0009-0002-7473-7016
Elena N KovalenkoFederal State Budgetary Educational Institution of Higher Education, National Research Ogarev Mordovia State University, Mordovia 430005, Russia.
Alina E MarkinaFederal State Budgetary Educational Institution of Higher Education, National Research Ogarev Mordovia State University, Mordovia 430005, Russia.
Sergey I PinyaevFederal State Budgetary Educational Institution of Higher Education, National Research Ogarev Mordovia State University, Mordovia 430005, Russia.ORCID 0000-0002-2347-5020
Olga V MinaevaFederal State Budgetary Educational Institution of Higher Education, National Research Ogarev Mordovia State University, Mordovia 430005, Russia.
Aleksey P VlasovFederal State Budgetary Educational Institution of Higher Education, National Research Ogarev Mordovia State University, Mordovia 430005, Russia.

Funding

Russian Science Foundation 24-25-00278
6 · The paper itself

Abstract

The low predictability of the effects of autologous platelet-rich plasma (PRP) in regenerative therapy for patients with type 1 and type 2 diabetes mellitus (DM) underscores the need for further research assessing the reparative effects of PRP based on the type of DM. The aim of this study was to evaluate the regenerative potential of PRP from young donors (30-40 years old) with DM1 and DM2 in vitro, specifically its effects on human dermal fibroblast cell culture. The in vitro effects of PRP from patients with type 1 and type 2 DM were investigated using a culture of human dermal fibroblasts (hTERT-HDFa) to evaluate metabolic activity, migration, proliferation of the cells, and their ability to release growth factors and exosomes. The study of the biological effects of PRP from donors with DM on hTERT-HDFa revealed a decrease in proliferative effects, an increase in prooxidant action, and toxic influences of PRP from patients, characterized by reduced metabolic activity and cell viability in culture, along with an increase in the percentage of necrosis. These effects were most pronounced in type 1 DM. The secretory response of hTERT-HDFa upon stimulation with PRP varied depending on the type of DM. Correlations indicated the differing significance of PAI-1, TGFB-1, PDGF, VEGF, and IL-6 in assessing the reparative potential across different types of DM.

Indexed as

Diabetes Mellitus, Type 1Diabetes Mellitus, Type 2Platelet-Rich PlasmaRegenerationAdultCell MovementCell ProliferationCells, CulturedCell SurvivalFemaleFibroblastsHumansMalediabetes mellituspersonalized medicineplatelet-rich plasmaPRP-therapyregenerative medicine

Identifiers

PMID40869177
PMCPMC12386270

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.