Evidence map›Paper›PMID 40869172›Full record

ArticleInternational journal of molecular sciences2025

Transcriptomic Response to Neuromuscular Electrical Stimulation in Muscle, Brain, and Plasma EVs in WT and Klotho-Deficient Mice.

Catherine Anne Cavanaugh, Amanda E Moore, Nicholas Francis Fitz, Iliya Lefterov, Radosveta Koldamova

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Catherine Anne CavanaughDepartment of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0009-0003-3512-6228
Amanda E MooreDepartment of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0009-0000-9421-0233
Nicholas Francis FitzDepartment of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0001-6938-6536
Iliya LefterovDepartment of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0002-0249-0280
Radosveta KoldamovaDepartment of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0002-6761-0984

Funding

Physical exercise and Blood-brain communication: exosomes, Klotho and choroid plexusR01AG066198 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AMBROSIO, FABRISIA, KOLDAMOVA, RADOSVETA · 2020 to 2024
$3.8M
ncRNAs in plasma EVs of AD patients and their discriminatory power as biomarkersRF1AG075992 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOLDAMOVA, RADOSVETA, LEFTEROV, ILIYA · 2022 to 2025
$3.7M
The interplay between Tau and ncRNAs – genomic and epigenomic clues to early AD pathogenesisR01AG077636 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RADOSVETA KOLDAMOVA, ILIYA LEFTEROV · 2022 to 2026
$3.5M
APOE Orchestrated Molecular Signatures in Aging Brain and AD-the Contribution of APOE2R01AG057565 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOLDAMOVA, RADOSVETA, LEFTEROV, ILIYA · 2018 to 2022
$3.2M
APOE orchestrated ''molecular signatures'' in aging brain and AD - the contribution of APOE2R56AG057565 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOLDAMOVA, RADOSVETA, LEFTEROV, ILIYA · 2017 to 2017
$441k
National Institute on Aging-National Institutes of Health AG057565National Institute on Aging-National Institutes of Health R01 AG075992NIA NIH HHS R01 AG057565NIA NIH HHS R01 AG066198NIA NIH HHS R01 AG077636NIA NIH HHS R56 AG057565NIA NIH HHS RF1 AG075992
6 · The paper itself

Abstract

Neuromuscular electrical stimulation (NMES) has been shown to improve motor activities and daily living. Prior studies indicated extracellular vesicles (EVs) play a role in cellular communication. Here, we evaluated transcriptomic profiles of tibialis muscle, brain, and plasma-derived EVs following NMES in wild type (WT) and

Indexed as

BrainExtracellular VesiclesGlucuronidaseMuscle, SkeletalTranscriptomeAnimalsElectric StimulationGene Expression ProfilingKlotho ProteinsMaleMiceMice, Inbred C57BLGlucuronidaseKlotho Proteinsbrainextracellular vesiclesKlothometabolismmuscleNMESnon-coding RNAsRNA-seq

Identifiers

PMID40869172
PMCPMC12386275

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.