Evidence map›Paper›PMID 40869050›Full record

ArticleInternational journal of molecular sciences2025

Chromosomal Aberrations in Induced Pluripotent Stem Cells: Identification of Breakpoints in the Large

Diana Zheglo, Victoria O Pozhitnova, Anastasiia V Kislova, Zhanna G Markova, Danila Kiselev, Philipp S Sviridov, Valeria Sviridova, Lyajsan I Gumerova, Svetlana A Smirnikhina, Almaqdad Alsalloum and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Diana ZhegloResearch Centre for Medical Genetics, Moskvorechie 1, Moscow 115478, Russia.
Victoria O PozhitnovaResearch Centre for Medical Genetics, Moskvorechie 1, Moscow 115478, Russia.ORCID 0000-0001-8286-7924
Anastasiia V KislovaResearch Centre for Medical Genetics, Moskvorechie 1, Moscow 115478, Russia.ORCID 0009-0003-0280-8951
Zhanna G MarkovaResearch Centre for Medical Genetics, Moskvorechie 1, Moscow 115478, Russia.ORCID 0000-0003-2941-2861
Danila KiselevResearch Centre for Medical Genetics, Moskvorechie 1, Moscow 115478, Russia.ORCID 0009-0001-0752-6916
Philipp S SviridovResearch Centre for Medical Genetics, Moskvorechie 1, Moscow 115478, Russia.
Valeria SviridovaResearch Centre for Medical Genetics, Moskvorechie 1, Moscow 115478, Russia.
Lyajsan I GumerovaResearch Centre for Medical Genetics, Moskvorechie 1, Moscow 115478, Russia.
Svetlana A SmirnikhinaResearch Centre for Medical Genetics, Moskvorechie 1, Moscow 115478, Russia.
Almaqdad AlsalloumFederal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Baltiyskaya St. 8, Moscow 125315, Russia.ORCID 0000-0002-9698-0634
Svetlana V PylinaEndocrinology Research Centre, Moscow 115478, Russia.ORCID 0000-0002-4920-2143
Sergey Ivanovich KutsevResearch Centre for Medical Genetics, Moskvorechie 1, Moscow 115478, Russia.
Ekaterina Sergeevna VoroninaResearch Centre for Medical Genetics, Moskvorechie 1, Moscow 115478, Russia.ORCID 0000-0002-5789-0927

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genome instability in induced pluripotent stem cells (IPSC) poses a significant challenge for their use in research and medicine. Cataloging and precisely describing all the identified aberrations that arise during cell reprogramming, expansion, and differentiation is essential for improving approaches to instability prevention and ensuring genetic quality control. We report the karyotypic analysis of 65 cell lines derived from skin fibroblasts, urinal sediment, and peripheral blood mononuclear cells of 33 individuals, 82% of whom suffer from monogenic genetic disorders not associated with genetic instability. Trisomy of chromosomes 20 and 8 was revealed recurrently, while the 1q arm was the most frequently affected region involved in interstitial duplications and unbalanced translocations with chromosomes 15 and 18. The localization of rearrangement breakpoints identified by SNP arrays within the large

Indexed as

Chromosome AberrationsChromosome BreakpointsHistonesInduced Pluripotent Stem CellsMultigene FamilyCell LineFemaleFibroblastsGenomic InstabilityHumansKaryotypingMalePolymorphism, Single NucleotideHistones1q gainbreakpointcommon fragile sitesDCCgenome instabilityhistoneinduced pluripotent stem cellskaryotypereplication stress

Identifiers

PMID40869050
PMCPMC12387029

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.