Evidence map›Paper›PMID 40869019›Full record

ArticleInternational journal of molecular sciences2025

Comparative Pain Expression and Its Association to Intestinal Microbiota Through the MI-RAT© Osteoarthritis Model Induced in LOU/C/Jall and Sprague-Dawley Aged Rats.

Marilyn Frézier, Colombe Otis, Emilie Labelle, Bertrand Lussier, Pierrette Gaudreau, Simon Authier, Marcio Carvalho Costa, Hélène Beaudry, Eric Troncy

Abstract readComparative Study
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marilyn FrézierGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, St.-Hyacinthe, QC J2S 2M2, Canada.ORCID 0000-0002-7141-7108
Colombe OtisGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, St.-Hyacinthe, QC J2S 2M2, Canada.ORCID 0000-0003-4286-6534
Emilie LabelleGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, St.-Hyacinthe, QC J2S 2M2, Canada.
Bertrand LussierGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, St.-Hyacinthe, QC J2S 2M2, Canada.ORCID 0000-0001-7319-3841
Pierrette GaudreauDepartment of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada.ORCID 0000-0001-9362-2287
Simon AuthierGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, St.-Hyacinthe, QC J2S 2M2, Canada.ORCID 0000-0001-8134-4558
Marcio Carvalho CostaGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, St.-Hyacinthe, QC J2S 2M2, Canada.ORCID 0000-0001-5067-7501
Hélène BeaudryGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, St.-Hyacinthe, QC J2S 2M2, Canada.ORCID 0000-0002-0869-3767
Eric TroncyGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, St.-Hyacinthe, QC J2S 2M2, Canada.ORCID 0000-0003-0209-5261

Funding

Canada Foundation for Innovation Leader Opportunity Fund grant #24601Canada Foundation for Innovation New Opportunities Fund grant #9483Fonds de recherche Québec Réseau Québécois de Recherche sur le VieillissementNatural Sciences and Engineering Research Council RGPIN #05512-2020Natural Sciences and Engineering Research Council RGPIN #441651-2013
6 · The paper itself

Abstract

To investigate the involvement of gut-brain axis in musculoskeletal chronic pain in the elderly, this preclinical study aimed to compare osteoarthritis (OA) pain expression, cognitive function and gut microbiota composition in two aging rat strains (11-15 months). A validated surgically induced OA model was used in Sprague-Dawley (SD;

Indexed as

AgingGastrointestinal MicrobiomeOsteoarthritisPainAnimalsDisease Models, AnimalMaleNeuropeptidesRatsRats, Sprague-DawleyNeuropeptidesagingcognitionconditioned pain modulationgut microbiotamusculoskeletalsomatosensory sensitization

Identifiers

PMID40869019
PMCPMC12386630

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.