Evidence map›Paper›PMID 40869007›Full record

ReviewInternational journal of molecular sciences2025

Micro/Nano-Motors for Enhanced Tumor Diagnosis and Therapy.

Zherui Zhang, Bulong Gao, Ruizhen Tian, Jiayun Xu, Tingting Wang, Tengfei Yan, Junqiu Liu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zherui ZhangCollege of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.
Bulong GaoKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, China.
Ruizhen TianKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, China.
Jiayun XuKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, China.
Tingting WangKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, China.
Tengfei YanKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, China.
Junqiu LiuKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, China.ORCID 0000-0003-1608-7908

Funding

Hangzhou Leading Innovation and Entrepreneurship Team Project TD2022001National Natural Science Foundation of China 22275046National Science Foundation for Young Scientists of China 22105056National Science Foundation for Young Scientists of China 22201058The Hangzhou Normal university postdoctoral research start-up fund 4095C5022421502The Interdisciplinary Research Project of Hangzhou Normal University 2024JCXK01
6 · The paper itself

Abstract

Cancer remains one of the most significant diseases threatening human health. The lack of effective diagnostic and therapeutic technologies is a critical factor contributing to the high clinical mortality rates associated with malignant tumors. Self-propelled micro/nano-motors (MNMs) hold promise for addressing the limitations of conventional nanoparticles in cancer diagnosis and treatment. Their unique motion characteristics enhance the efficiency of MNMs in achieving rapid distribution, deep tissue penetration, and targeted delivery in vivo. This review systematically summarizes recent advances in MNM-based therapy for tumor diagnosis and treatment, offering a comprehensive overview of their material classification, self-propelled mechanisms, targeting strategies, and therapeutic approaches. Subsequently, we discuss the therapeutic mechanisms of MNMs within the tumor microenvironment in detail and highlight the advantages of synergistic multimodal therapies, including chemodynamic therapy, sonodynamic therapy, photothermal therapy, immunotherapy, photodynamic therapy, and gas therapy. Finally, we outline the main challenges and prospects for the development of MNMs in cancer diagnosis and therapy.

Indexed as

NanoparticlesNeoplasmsAnimalsCombined Modality TherapyHumansImmunotherapyPhotochemotherapyTumor Microenvironmentcancer diagnosis and therapymicro/nano-motorssynergistic therapy

Identifiers

PMID40869007
PMCPMC12386485

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.