Evidence map›Paper›PMID 40868992›Full record

ArticleInternational journal of molecular sciences2025

The Sweet Side of IVF: Biological Role and Diagnostic Potential of Galectin-9 in Female Infertility.

Beata Polgar, Matyas Meggyes, Krisztina Godony, Akos Varnagy, Kalman Kovacs, Peter Mauchart, Peter Matrai, Krisztina Kovacs, David Semjen, Tamas Tornoczki and 1 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Beata PolgarDepartment of Medical Microbiology, Medical School, University of Pecs, 12 Szigeti Street, 7624 Pecs, Hungary.ORCID 0000-0002-8687-7430
Matyas MeggyesDepartment of Medical Microbiology, Medical School, University of Pecs, 12 Szigeti Street, 7624 Pecs, Hungary.ORCID 0000-0002-9913-2024
Krisztina GodonyDepartment of Obstetrics and Gynecology, Medical School, University of Pecs, 17 Édesanyák Street, 7624 Pecs, Hungary.
Akos VarnagyDepartment of Obstetrics and Gynecology, Medical School, University of Pecs, 17 Édesanyák Street, 7624 Pecs, Hungary.
Kalman KovacsDepartment of Obstetrics and Gynecology, Medical School, University of Pecs, 17 Édesanyák Street, 7624 Pecs, Hungary.
Peter MauchartDepartment of Obstetrics and Gynecology, Medical School, University of Pecs, 17 Édesanyák Street, 7624 Pecs, Hungary.
Peter MatraiInstitute of Bioanalysis, Medical School, University of Pecs, 12 Szigeti Street, 7624 Pecs, Hungary.
Krisztina KovacsDepartment of Pathology, Medical School and Clinical Centre, University of Pecs, 12 Szigeti Street, 7624 Pecs, Hungary.
David SemjenDepartment of Pathology, Medical School and Clinical Centre, University of Pecs, 12 Szigeti Street, 7624 Pecs, Hungary.
Tamas TornoczkiDepartment of Pathology, Medical School and Clinical Centre, University of Pecs, 12 Szigeti Street, 7624 Pecs, Hungary.
Laszlo SzeredayDepartment of Medical Microbiology, Medical School, University of Pecs, 12 Szigeti Street, 7624 Pecs, Hungary.ORCID 0000-0002-1208-2969

Funding

Human Academy of Sciences, University of Pecs, Human Reproduction Scientific Research Group n.a.University of Pecs Medical School Research Grant AOK-KA-2013/21, KA-2019/48, KA-2021/38, KA-2024-09
6 · The paper itself

Abstract

Infertility rates are indeed increasing globally, which emphasizes a pressing need to identify novel biomarkers exhibiting superior potential for laboratory diagnosis and personalized clinical management. This study aimed to explore the biological role of Galectin-9 (Gal-9) in female fertility and evaluate its diagnostic potential in the In Vitro Fertilization (IVF) program. A prospective cohort study was performed on 83 follicular fluids (FF) and 19 serum-FF pairs from IVF patients, 16 serum samples from fertile women, and 12 tissue sections. Gal-9 expression was characterized by immunostaining and ELISA. The ROC analysis was employed to evaluate the overall diagnostic performance. Cell-specific ovarian Gal-9 expression and significant differences in soluble Gal-9 levels were identified in the serum and FF of fertile and infertile women. Elevated intrafollicular Gal-9 levels were linked to poor ovarian reserve, served as a predictive marker for ovarian hyperstimulation, and marked unfavorable IVF outcomes. Follicular Gal-9 levels positively correlated with peak estradiol and total daily FSH dosage. ROC analysis revealed an excellent diagnostic value of Gal-9 for predicting fertilization success and a moderate ability to predict IVF outcomes. Our findings suggest a potential role for Gal-9 in oogenesis and its promise as a diagnostic marker for predicting fertilization success in IVF. However, further studies are needed to confirm its clinical utility in assisted reproduction.

Indexed as

Fertilization in VitroGalectinsInfertility, FemaleAdultBiomarkersFemaleFollicular FluidHumansOvarian ReserveProspective StudiesROC CurveBiomarkersGalectinsLGALS9 protein, humanbiomarkerfollicular fluidGalectin-9infertilityin vitro fertilization

Identifiers

PMID40868992
PMCPMC12386815

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.