Evidence map›Paper›PMID 40868949›Full record

ArticleLife (Basel, Switzerland)2025

Causal Association of Free Triiodothyronine Level with Ischemic Stroke Outcome: A Mendelian Randomization Study.

Dmitry A Filimonov, Vitaly V Morozov, Roman V Ishchenko, Alexander B Eresko, Nadezhda N Trubnikova, Margarita A Belotserkovskaya, Maksim V Solopov, Irina A Kisilenko, Inna N Nosova, Dmitry A Kudlay

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dmitry A FilimonovFederal State Budgetary Institution "V.K. Gusak Institute of Emergency and Reconstructive Surgery" of the Ministry of Health of the Russian Federation, Donetsk 283045, Russia.
Vitaly V MorozovThe Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Science, Novosibirsk 630090, Russia.
Roman V IshchenkoFederal State Budgetary Institution "V.K. Gusak Institute of Emergency and Reconstructive Surgery" of the Ministry of Health of the Russian Federation, Donetsk 283045, Russia.
Alexander B EreskoJoint Institute for Nuclear Research, Dubna 141980, Russia.
Nadezhda N TrubnikovaFederal State Budgetary Institution "V.K. Gusak Institute of Emergency and Reconstructive Surgery" of the Ministry of Health of the Russian Federation, Donetsk 283045, Russia.
Margarita A BelotserkovskayaFederal State Budgetary Institution "V.K. Gusak Institute of Emergency and Reconstructive Surgery" of the Ministry of Health of the Russian Federation, Donetsk 283045, Russia.
Maksim V SolopovFederal State Budgetary Institution "V.K. Gusak Institute of Emergency and Reconstructive Surgery" of the Ministry of Health of the Russian Federation, Donetsk 283045, Russia.ORCID 0000-0001-7053-4428
Irina A KisilenkoFederal State Budgetary Institution "V.K. Gusak Institute of Emergency and Reconstructive Surgery" of the Ministry of Health of the Russian Federation, Donetsk 283045, Russia.
Inna N NosovaFederal State Budgetary Institution "V.K. Gusak Institute of Emergency and Reconstructive Surgery" of the Ministry of Health of the Russian Federation, Donetsk 283045, Russia.
Dmitry A KudlayDepartment of Pharmacology, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenovskiy University), Moscow 119991, Russia.

Funding

Ministry of Health of the Russian Federation 1023042500162-8-3.1.4;3.2.25 (2023-2025)
6 · The paper itself

Abstract

The global burden of ischemic stroke requires a search for new factors that affect its risk and outcomes. Recent studies have shown that triiodothyronine could potentiate favorable stroke outcomes, but the reason for this is still unclear. To clarify the effects of the free triiodothyronine (fT3) level on stroke outcomes, we adopted a Mendelian randomization (MR) approach to evaluate their causal relationship. The genetic variants associated with the free triiodothyronine (fT3) level were obtained from the ThyroidOmics Consortium. Thirteen single-nucleotide polymorphisms, genetically predicting the fT3 level with a significance of

Indexed as

genetic variantsischemic strokeMendelian randomizationneuroprotectionthyroid hormonestriiodothyronine

Identifiers

PMID40868949
PMCPMC12387972

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.