ArticleGels (Basel, Switzerland)2025
Effect of Phosphate Phase Incorporation on 3D-Printed Hydrogel Scaffolds: Towards Customizable Bone Graft Materials.
Article in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Frontal Polymerization-Enabled Rapid Fabrication of Gelatin-Containing Hydrogels with Good Mechanical and Biological Properties.Gels (Basel, Switzerland) · 2026Article
- MAPLE Deposition of Resorbable Calcium Phosphates on Electrospun Nylon Nanofibres for Bone Tissue Engineering.Materials (Basel, Switzerland) · 2026Article
- Volumetric Control vs. Pneumatic Pressure: A Comparative Analysis of Extrusion in 3D Bioprinting.Micromachines · 2026Article
- Quantitative Assessment of Hydrogel Printability in Extrusion Bioprinting.Gels (Basel, Switzerland) · 2026Review
- Design and Fabrication of Biomimetic Gradient Bone Tissue Engineering Scaffolds: Evolution from Single-Gradient to Multi-Gradient.Gels (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Bone defects remain a significant clinical challenge, creating a severe need for advanced biomaterials for tissue regeneration. This study addresses this issue by developing 3D-printed composite hydrogels containing alginate, gelatine, and resorbable calcium phosphates (monetite and brushite) for bone tissue engineering. The scaffolds were fabricated using extrusion-based 3D printing and evaluated for their morphology, porosity, mechanical strength, swelling, degradation, and in vitro mineralization, while their cytocompatibility was assessed using LIVE/DEAD cell viability assays. The key findings demonstrate that calcium phosphate incorporation enhanced the mechanical stability by 15-25% compared to the controls, and mineral deposition increased significantly in the composite scaffolds. The developed hydrogels are bioactive and represent promising, customizable scaffolds for bone regeneration. These results support their further investigation as viable alternatives to traditional bone grafts for clinical bone tissue engineering applications.
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Registered trials
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