Advances in Hydrogel-Based Delivery of RNA Drugs for Antitumor Therapy.

Tumors are a major disease that seriously threatens human health, with their incidence and mortality rates increasing year by year. However, traditional therapies such as surgery, chemotherapy, and radiotherapy have significant limitations, including significant side effects and propensity for drug resistance. In recent years, with the rapid development of medical technology, RNA therapy has shown great potential as an emerging treatment method in anti-tumor therapy, bringing new hope for tumor treatment. RNA therapy mainly includes small interfering RNA, antisense oligonucleotides, and aptamers. Hydrogels, as a polymer material with three-dimensional network structure, have good biocompatibility and can effectively improve the efficiency of RNA delivery. This review specifically focuses on the application of hydrogels as RNA carriers in anti-tumor therapy, along with the classification, delivery advantages, and challenges. However, despite existing deficiencies in safety and targeting, hydrogel-mediated RNA delivery for tumor treatment still shows unique advantages and broad application prospects. In the future, research and cutting-edge innovations are expected to facilitate precision oncology solutions, offering superior treatment options and catalyzing the evolution of cancer management strategies.