Evidence map›Paper›PMID 40868719›Full record

ReviewGels (Basel, Switzerland)2025

Hydrogel Network Architecture Design Space: Impact on Mechanical and Viscoelastic Properties.

Andres F Roca-Arroyo, Jhonatan A Gutierrez-Rivera, Logan D Morton, David A Castilla-Casadiego

Abstract readReview
In one paragraph

Review in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

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  8. Ultrasound-responsive composite hydrogels: Design rules for spatiotemporally controlled drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Andres F Roca-ArroyoDepartment of Biomedical Engineering, University of Miami, Coral Gables, FL 33146, USA.ORCID 0009-0006-0421-6169
Jhonatan A Gutierrez-RiveraDepartment of Biomedical Engineering, University of Miami, Coral Gables, FL 33146, USA.
Logan D MortonDepartment of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.ORCID 0000-0003-0767-9709
David A Castilla-CasadiegoDepartment of Biomedical Engineering, University of Miami, Coral Gables, FL 33146, USA.ORCID 0000-0003-2350-5194

Funding

Dynamic Nanofibrous Hydrogels for Enhancing Stem Cells' Therapeutic PotencyR00GM151459 · NIGMS · UNIVERSITY OF MIAMI CORAL GABLES · PI David Castilla-Casadiego · 2025 to 2026
$498k
NIGMS NIH HHS R00 GM151459NIH HHS 1R00GM151459-01
6 · The paper itself

Abstract

This comprehensive review explores the expansive design space of network architectures and their significant impact on the mechanical and viscoelastic properties of hydrogel systems. By examining the intricate relationships between molecular structure, network connectivity, and resulting bulk properties, we provide critical insights into rational design strategies for tailoring hydrogel mechanics for specific applications. Recent advances in sequence-defined crosslinkers, dynamic covalent chemistries, and biomimetic approaches have significantly expanded the toolbox for creating hydrogels with precisely controlled viscoelasticity, stiffness, and stress relaxation behavior-properties that are crucial for biomedical applications, particularly in tissue engineering and regenerative medicine.

Indexed as

biomimeticcrosslinker architectureextracellular matrix mimichydrogelstructure–property relationshipsviscoelasticity

Identifiers

PMID40868719
PMCPMC12385289

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.