ArticleChildren (Basel, Switzerland)2025
Relationship of Melatonin Levels in Blood and Urine with Sleep Quality in Children Admitted to Pediatric Intensive Care Unit.
Article in Children (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesMelatonin regulates the sleep-wake cycle, which may be altered in children admitted to the pediatric intensive care unit (PICU). The aim is to analyze whether blood and urine melatonin levels are related to sleep quality in children admitted to the PICU.
methodsA single-center, prospective observational study was conducted at the PICU in a tertiary referral center in Madrid, Spain. It included patients (1 month-16 years) admitted to the PICU.
resultsA total of 40 children were included in the study (52.5% male), analyzing 2 days for each patient (80 total study days). The median age of the patients was 34.5 months. The median number of hours of sleep over the whole day was 9.9 h (IQR 8.4-12.6); nighttime was 7.5 h (IQR 6.5-9) and daytime was 2.5 h (IQR 1.4-5.7). Only 8.5% of patients slept the appropriate number of hours of nighttime sleep for their age. High serum melatonin levels in the morning were correlated with more nocturnal awakenings (r = 0.35,
conclusionsChildren admitted to the PICU often do not achieve the recommended hours of sleep for their age. A significant percentage of these children exhibit an altered melatonin secretion pattern, which is associated with shorter nighttime sleep duration and longer daytime sleep duration.
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