Evidence map›Paper›PMID 40868478›Full record

ArticleChildren (Basel, Switzerland)2025

Trends in Term-Equivalent Age Brain Volumes in Infants Born Across the Gestational Age Spectrum.

Anouk S Verschuur, Gerda van Wezel-Meijler, Selma Low, Ingrid M Nijholt, Amy Metcalfe, Janice Skiffington, Donna M Slater, Amy Bergeron, Elsa Fiedrich, Martijn F Boomsma and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Children (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anouk S VerschuurDepartment of Radiology, Isala Hospital, Dokter van Heesweg 2, 8025 AB Zwolle, The Netherlands.ORCID 0000-0001-8737-7078
Gerda van Wezel-MeijlerDepartment of Neonatology, Isala Women and Children's Hospital, Dokter van Heesweg 2, 8025 AB Zwolle, The Netherlands.ORCID 0000-0002-4380-7758
Selma LowDepartment of Obstetrics and Gynecology, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada.
Ingrid M NijholtDepartment of Radiology, Isala Hospital, Dokter van Heesweg 2, 8025 AB Zwolle, The Netherlands.ORCID 0000-0003-4820-7505
Amy MetcalfeDepartment of Physiology and Pharmacology, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada.
Janice SkiffingtonDepartment of Obstetrics and Gynecology, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada.
Donna M SlaterDepartment of Obstetrics and Gynecology, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada.ORCID 0000-0003-2811-3632
Amy BergeronDepartment of Obstetrics and Gynecology, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada.
Elsa FiedrichDepartment of Pediatrics, Section of Newborn Critical Care, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada.
Martijn F BoomsmaDepartment of Radiology, Isala Hospital, Dokter van Heesweg 2, 8025 AB Zwolle, The Netherlands.ORCID 0000-0002-7878-0970
Chantal M W TaxImage Sciences Institute, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Alexander LeemansImage Sciences Institute, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Lara M LeijserDepartment of Pediatrics, Section of Newborn Critical Care, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada.ORCID 0000-0001-5458-3721

Funding

Alberta Children's Hospital Foundation n/aCalgary Health Foundation n/aIsala Science and Innovation Fund n/aNewborn Brain Society Early Career Award n/aRoyal Netherlands Academy of Arts and Sciences KNAWWF/1327/TMB202126Science Fund Medical Specialists Isala n/aWellcome TrustWellcome Trust 215944/Z/19/Z
6 · The paper itself

Abstract

purposeOur understanding of the influence of preterm birth and related perinatal exposures on early brain development is limited, hampering personalized optimization of neuroprotective strategies. This study assesses the effect of gestational age (GA) at birth on brain volumes at term-equivalent age (TEA) in infants without overt brain injury born across the GA spectrum.

methodsA cohort of infants born across the GA spectrum (25-40 weeks' gestation) underwent 3T brain MRI around TEA (40-46 weeks postmenstrual age). Eight brain regions, intracranial and total tissue volumes were segmented using MANTiS (morphologically adaptive neonatal tissue segmentation toolbox). Segmentations were visually quality-checked and excluded if segmentation failed. Absolute TEA volume in relation to GA was assessed using univariate and multivariate (correction for postmenstrual age) linear regression analysis. Statistical significance was set at

resultsFifty infants were included (mean GA = 35.0 [SD = 3.3, range = 25.7-40.1] weeks). A higher GA at birth was significantly related to lower cerebrospinal fluid (

conclusionsOur results suggest that GA has an effect on TEA brain volumes that is independent of brain lesions, with lower GA being associated with smaller brain tissue volumes and significantly larger cerebrospinal fluid volume. Preterm birth and related exposures may thus affect early brain growth and contribute to neurodevelopmental challenges encountered by preterm-born children.

Indexed as

braingestational ageMRIneonatalterm-equivalent agevolume

Identifiers

PMID40868478
PMCPMC12384106

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.