Quantitative Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) in Hepatocellular Carcinoma: A Review of Emerging Applications for Locoregional Therapy.

Xinyi M Li, Tu Nguyen, Hiro D Sparks, Kyunghyun Sung, Jason Chiang

Abstract readReview

In one paragraph

Review in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xinyi M LiDepartment of Radiological Sciences, University of California, Los Angeles, CA 92521, USA.ORCID 0000-0002-7934-5903

Tu NguyenDepartment of Radiological Sciences, University of California, Los Angeles, CA 92521, USA.

Hiro D SparksDepartment of Radiological Sciences, University of California, Los Angeles, CA 92521, USA.

Kyunghyun SungDepartment of Radiological Sciences, University of California, Los Angeles, CA 92521, USA.ORCID 0000-0003-4175-5322

Jason ChiangDepartment of Radiological Sciences, University of California, Los Angeles, CA 92521, USA.ORCID 0000-0003-2896-1930

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026

$118.1M

NCATS NIH HHS UL1 TR001881NIH HHS NIH UL1TR001881Radiological Society of North America Research Scholar Grant RSCH2303UCLA Department of Radiological Sciences Exploratory Grant Program UCLA Department of Radiological Sciences Exploratory Grant Program

6 · The paper itself

Abstract

Quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is emerging as a valuable tool for assessing tumor and parenchymal perfusion in the liver, playing a developing role in locoregional therapies (LRTs) for hepatocellular carcinoma (HCC). This review explores the conceptual underpinnings and early investigational stages of DCE-MRI for LRTs, including thermal ablation, transarterial chemoembolization (TACE), and transarterial radioembolization (TARE). Preclinical and early-phase studies suggest that DCE-MRI may offer valuable insights into HCC tumor microvasculature, treatment response, and therapy planning. In thermal ablation therapies, DCE-MRI provides a quantitative measurement of tumor microvasculature and perfusion, which can guide more effective energy delivery and estimation of ablation margins. For TACE, DCE-MRI parameters are proving their potential to describe treatment efficacy and predict recurrence, especially when combined with adjuvant therapies. In

Indexed as

dynamic contrast-enhanced MRI (DCE-MRI)hepatocellular carcinoma (HCC)imaging biomarkerlocoregional therapythermal ablationtransarterial chemoembolization (TACE)transarterial radioembolization (TARE)tumor perfusion

Identifiers

PMID40868383

DOI10.3390/bioengineering12080870

PMCPMC12383434

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.