Evidence map›Paper›PMID 40868371›Full record

ReviewBioengineering (Basel, Switzerland)2025

Pregnancy-Related Spinal Biomechanics: A Review of Low Back Pain and Degenerative Spine Disease.

Ezra T Yoseph, Rukayat Taiwo, Ali Kiapour, Gavin Touponse, Elie Massaad, Marinos Theologitis, Janet Y Wu, Theresa Williamson, Corinna C Zygourakis

Abstract readReview
In one paragraph

Review in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. An adaptive attention U-network for recognizing ultrasound images.The Journal of international medical research · 2026
    Article
  3. Recent Findings and Developments in Spine Biomechanics.Bioengineering (Basel, Switzerland) · 2026
    Article
  4. Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ezra T YosephDepartment of Neurosurgery, Stanford University Medical Center, Stanford, CA 94305, USA.ORCID 0000-0002-4184-9292
Rukayat TaiwoDepartment of Neurosurgery, Stanford University Medical Center, Stanford, CA 94305, USA.
Ali KiapourDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-7837-9191
Gavin TouponseDepartment of Neurosurgery, Stanford University Medical Center, Stanford, CA 94305, USA.ORCID 0000-0001-8087-3351
Elie MassaadDepartment of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Marinos TheologitisDepartment of Neurosurgery, Stanford University Medical Center, Stanford, CA 94305, USA.
Janet Y WuDepartment of Neurosurgery, Stanford University Medical Center, Stanford, CA 94305, USA.ORCID 0000-0002-0626-6497
Theresa WilliamsonDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA.
Corinna C ZygourakisDepartment of Neurosurgery, Stanford University Medical Center, Stanford, CA 94305, USA.ORCID 0000-0002-1894-9252

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pregnancy induces substantial anatomical, hormonal, and biomechanical changes in the spine and pelvis to accommodate fetal growth and maintain postural adaptation. This narrative review synthesizes peer-reviewed evidence regarding pregnancy-related spinal biomechanics, with a particular focus on low back pain, spinopelvic alignment, sacroiliac joint dysfunction, and potential contributions to degenerative spinal conditions. A systematic search of PubMed, Embase, and Google Scholar was conducted using Boolean operators and relevant terms, yielding 1050 unique records, with 53 peer-reviewed articles ultimately cited. The review reveals that increased lumbar lordosis, ligamentous laxity, altered gait mechanics, and muscular deconditioning elevate mechanical load on the lumbar spine, predisposing up to 56% of pregnant individuals to low back pain. These changes are often associated with sacroiliac joint laxity, anterior pelvic tilt, and multiparity. Long-term risks may include degenerative disc disease and spondylolisthesis. Conservative interventions such as pelvic floor muscle training, prenatal exercise, and surface topography monitoring offer symptom relief and support early rehabilitation, although standardized protocols and longitudinal outcome data remain limited. Pregnancy-related spinal changes are multifactorial and clinically relevant; an interdisciplinary approach involving spinal biomechanics, physical therapy, and obstetric care is critical for optimizing maternal musculoskeletal health.

Indexed as

degenerative spondylolisthesisLBPlow back painlumbar lordosispelvic tiltpregnancy biomechanicsspinopelvic parameters

Identifiers

PMID40868371
PMCPMC12383562

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.