Evidence map›Paper›PMID 40868361›Full record

ArticleBioengineering (Basel, Switzerland)2025

Healing Kinetics of Sinus Lift Augmentation Using Biphasic Calcium Phosphate Granules: A Case Series in Humans.

Michele Furlani, Valentina Notarstefano, Nicole Riberti, Emira D'Amico, Tania Vanessa Pierfelice, Carlo Mangano, Elisabetta Giorgini, Giovanna Iezzi, Alessandra Giuliani

Abstract read
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Michele FurlaniBiomedical Science and Public Health Department, Polytechnic University of Marche, 60126 Ancona, Italy.ORCID 0000-0002-9261-2682
Valentina NotarstefanoLife and Environmental Sciences Department, Polytechnic University of Marche, 60131 Ancona, Italy.
Nicole RibertiDepartment of Clinical and Molecular Sciences, Polytechnic University of Marche, 60126 Ancona, Italy.ORCID 0000-0002-4798-5236
Emira D'AmicoMedical, Oral and Biotechnological Sciences Department, University "G. D'Annunzio" of Chieti-Pescara, 66013 Chieti, Italy.ORCID 0000-0003-2414-7130
Tania Vanessa PierfeliceMedical, Oral and Biotechnological Sciences Department, University "G. D'Annunzio" of Chieti-Pescara, 66013 Chieti, Italy.ORCID 0000-0002-5886-2186
Carlo ManganoDepartment of Dental Sciences, San Raffaele University, 20132 Milan, Italy.ORCID 0000-0002-4419-4674
Elisabetta GiorginiLife and Environmental Sciences Department, Polytechnic University of Marche, 60131 Ancona, Italy.ORCID 0000-0003-0503-5870
Giovanna IezziMedical, Oral and Biotechnological Sciences Department, University "G. D'Annunzio" of Chieti-Pescara, 66013 Chieti, Italy.
Alessandra GiulianiOdontostomatologic and Specialized Clinical Sciences Department, Polytechnic University of Marche, 60131 Ancona, Italy.ORCID 0000-0003-4177-7441

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sinus augmentation provides a well-established model for investigating the three-dimensional morphometry and macromolecular dynamics of bone regeneration, particularly when using biphasic calcium phosphate (BCP) graft substitutes. This case series included six biopsies from patients who underwent maxillary sinus augmentation using BCP granules composed of 30% hydroxyapatite (HA) and 70% β-tricalcium phosphate (β-TCP). Bone core biopsies were obtained at healing times of 6 months, 9 months, and 12 months. Histological evaluation yielded qualitative and quantitative insights into new bone distribution, while micro-computed tomography (micro-CT) and Raman microspectroscopy (RMS) were employed to assess the three-dimensional architecture and macromolecular composition of the regenerated bone. Micro-CT analysis revealed progressive maturation of the regenerated bone microstructure over time. At 6 months, the apical regenerated area exhibited a significantly higher mineralized volume fraction (58 ± 5%) compared to the basal native bone (44 ± 11%;

Indexed as

biphasic calcium phosphatebone healingbone regenerationmicro computed tomographyRaman microspectroscopysinus lift augmentation

Identifiers

PMID40868361
PMCPMC12383563

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.