Evidence map›Paper›PMID 40868355›Full record

ArticleBioengineering (Basel, Switzerland)2025

Ultrasonic Surgical Aspirator in Intramedullary Spinal Cord Tumours Treatment: A Simulation Study of Vibration and Temperature Field.

Ludovica Apa, Sergio Di Nitto, Mauro Palmieri, Pietro Familiari, Emanuele Rizzuto, Zaccaria Del Prete

Erratum issuedAbstract read
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Ludovica ApaDepartment of Mechanical and Aerospace Engineering, University of Rome La Sapienza, Via Eudossiana 18, 00184 Rome, Italy.ORCID 0000-0002-4249-5596
Sergio Di NittoDepartment of Mechanical and Aerospace Engineering, University of Rome La Sapienza, Via Eudossiana 18, 00184 Rome, Italy.
Mauro PalmieriDepartment of Human Neurosciences, Division of Neurosurgery, Policlinico Umberto I University Hospital, Sapienza University of Rome, 00157 Rome, Italy.ORCID 0000-0001-5131-1392
Pietro FamiliariDepartment of Human Neurosciences, Division of Neurosurgery, Policlinico Umberto I University Hospital, Sapienza University of Rome, 00157 Rome, Italy.ORCID 0000-0003-0513-2312
Emanuele RizzutoDepartment of Mechanical and Aerospace Engineering, University of Rome La Sapienza, Via Eudossiana 18, 00184 Rome, Italy.ORCID 0000-0003-2314-6128
Zaccaria Del PreteDepartment of Mechanical and Aerospace Engineering, University of Rome La Sapienza, Via Eudossiana 18, 00184 Rome, Italy.ORCID 0000-0001-6057-7774

Funding

Sapienza, University of Rome "Progetti di Ricerca Medi 2024", Sapienza University of Rome
6 · The paper itself

Abstract

The aim of this work is to analyse the effectiveness of the medical use of the Cavitron Ultrasonic Surgical Aspirator (CUSA) in microsurgical treatment of Intramedullary Spinal Cord Tumors (IMSCTs), with a focus on the thermo-mechanical effects on neighbouring tissues to assess any potential damage. Indeed, CUSA emerges as an innovative solution, minimally invasive tumor excision technique, enabling controlled and focused operations. This study employs a Finite Element Analysis (FEA) to simulate the vibratory and thermal interactions occurring during CUSA application. A computational model of a vertebral column segment affected by an IMSCT was developed and analysed using ANSYS 2024 software. The simulations examined strain distribution, heat generation, and temperature propagation within the biological tissues. The FEA results demonstrate that the vibratory-induced strain remains highly localised to the application site, and thermal effects, though measurable, do not exceed the critical safety threshold of 46 °C established in the literature. These findings suggest that CUSA can be safely used within defined operational parameters, provided that energy settings and exposure times are carefully managed to mitigate excessive thermal accumulation. These conclusions contribute to the understanding of the thermo-mechanical interactions in ultrasonic tumour resection and aim to assist medical professionals in optimising surgical protocols.

Indexed as

Cavitron Ultrasonic Surgical Aspirator (CUSA)Finite Element Analysis (FEA)human spinal cord modelIntramedullary Spinal Cord Tumors (IMSCTs)microsurgical resectionstrain and temperature measurements

Identifiers

PMID40868355
PMCPMC12383581

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.