Evidence map›Paper›PMID 40868320›Full record

ArticleBioengineering (Basel, Switzerland)2025

A Fully Automated Analysis Pipeline for 4D Flow MRI in the Aorta.

Ethan M I Johnson, Haben Berhane, Elizabeth Weiss, Kelly Jarvis, Aparna Sodhi, Kai Yang, Joshua D Robinson, Cynthia K Rigsby, Bradley D Allen, Michael Markl

Abstract read
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Synthetically trained convolutional neural networks for time-resolved aortic segmentation of four-dimensional flow magnetic resonance imaging.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ethan M I JohnsonDepartment of Radiology, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-3701-0961
Haben BerhaneDepartment of Radiology, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-1381-7373
Elizabeth WeissDepartment of Radiology, Northwestern University, Chicago, IL 60611, USA.
Kelly JarvisDepartment of Radiology, Northwestern University, Chicago, IL 60611, USA.
Aparna SodhiDepartment of Medical Imaging, Lurie Children's Hospital, Chicago, IL 60611, USA.
Kai YangDepartment of Radiology, Northwestern University, Chicago, IL 60611, USA.ORCID 0009-0001-6296-0846
Joshua D RobinsonDepartment of Radiology, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-2129-5501
Cynthia K RigsbyDepartment of Radiology, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0003-1224-2333
Bradley D AllenDepartment of Radiology, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-0667-137X
Michael MarklDepartment of Radiology, Northwestern University, Chicago, IL 60611, USA.

Funding

Functional Cardiovascular 4D MRI in Congenital Heart DiseaseR01HL115828 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MARKL, MICHAEL, RIGSBY, CYNTHIA K · 2012 to 2021
$5.2M
Role of Valve-Mediated Hemodynamics on Bicuspid AortopathyR01HL133504 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BARKER, ALEXANDER J., FEDAK, PAUL WILLIAM MICHAEL · 2017 to 2021
$2.8M
Anatomic Imaging Derived 4D Hemodynamics using Deep LearningR42HL174259 · NHLBI · THIRD COAST DYNAMICS, INC. · PI Bradley David Allen · 2024 to 2026
$2.2M
Linking in vivo hemodynamics with outcomes in Type B aortic dissection using 4D flow MRIR01HL168700 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Bradley David Allen · 2024 to 2026
$2.0M
Graduate Training Program for Magnetic Resonance ImagingT32EB025766 · NIBIB · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Michael Markl · 2019 to 2026
$1.6M
Northwestern University Molecular and Translational Cardiovascular Training ProgramT32HL134633 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MCNALLY, ELIZABETH M · 2017 to 2021
$1.6M
Heart-brain MRI for the evaluation of hemodynamic coupling in aging and Alzheimer's diseaseK01AG080070 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Kelly Brooke Jarvis · 2023 to 2026
$496k
NHLBI NIH HHS R01 HL115828NHLBI NIH HHS R01 HL133504NHLBI NIH HHS R01 HL168700NHLBI NIH HHS R42 HL174259NHLBI NIH HHS T32 HL134633NIA NIH HHS K01 AG080070NIBIB NIH HHS T32 EB025766NIH HHS 1R01HL115828-01NIH HHS 1R01HL133504-01NIH HHS 1T32HL134633-01
6 · The paper itself

Abstract

Four-dimensional (4D) flow MRI has shown promise for the assessment of aortic hemodynamics. However, data analysis traditionally requires manual and time-consuming human input at several stages. This limits reproducibility and affects analysis workflows, such that large-cohort 4D flow studies are lacking. Here, a fully automated artificial intelligence (AI) 4D flow analysis pipeline was developed and evaluated in a cohort of over 350 subjects. The 4D flow MRI analysis pipeline integrated a series of previously developed and validated deep learning networks, which replaced traditionally manual processing tasks (background-phase correction, noise masking, velocity anti-aliasing, aorta 3D segmentation). Hemodynamic parameters (global aortic pulse wave velocity (PWV), peak velocity, flow energetics) were automatically quantified. The pipeline was evaluated in a heterogeneous single-center cohort of 379 subjects (age = 43.5 ± 18.6 years, 118 female) who underwent 4D flow MRI of the thoracic aorta (

Indexed as

4D flow MRIAI-driven automationautomated analysis

Identifiers

PMID40868320
PMCPMC12383084

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.