Evidence map›Paper›PMID 40868014›Full record

ArticleAntibiotics (Basel, Switzerland)2025

The Small Molecule Inhibitor of the Type III Secretion System Fluorothiazinone Affects Flagellum Surface Presentation and Restricts Motility in Gram-Negative Bacteria.

Alexey Slonov, Mariam Abdulkadieva, Egor Kalinin, Natalya Bondareva, Lydia Kapotina, Svetlana Andreevskaya, Natalia Shevlyagina, Anna Sheremet, Elena Sysolyatina, Vladimir Zhukhovitsky and 5 more

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In one paragraph

Article in Antibiotics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Alexey SlonovDepartment of Infections with Natural Foci, Gamaleya National Research Center of Epdemiology and Microbiology, Gamaleya st. 18, Moscow 123098, Russia.
Mariam AbdulkadievaDepartment of Infections with Natural Foci, Gamaleya National Research Center of Epdemiology and Microbiology, Gamaleya st. 18, Moscow 123098, Russia.
Egor KalininDepartment of Infections with Natural Foci, Gamaleya National Research Center of Epdemiology and Microbiology, Gamaleya st. 18, Moscow 123098, Russia.
Natalya BondarevaDepartment of Medical Microbiology, Gamaleya National Research Center of Epdemiology and Microbiology, Gamaleya st. 18, Moscow 123098, Russia.
Lydia KapotinaDepartment of Medical Microbiology, Gamaleya National Research Center of Epdemiology and Microbiology, Gamaleya st. 18, Moscow 123098, Russia.
Svetlana AndreevskayaDepartment of Bacterial Infections, Gamaleya National Research Center of Epdemiology and Microbiology, Gamaleya st. 18, Moscow 123098, Russia.ORCID 0000-0003-4704-4329
Natalia ShevlyaginaDepartment of Bacterial Infections, Gamaleya National Research Center of Epdemiology and Microbiology, Gamaleya st. 18, Moscow 123098, Russia.
Anna SheremetDepartment of Medical Microbiology, Gamaleya National Research Center of Epdemiology and Microbiology, Gamaleya st. 18, Moscow 123098, Russia.ORCID 0000-0002-5210-5010
Elena SysolyatinaDepartment of Infections with Natural Foci, Gamaleya National Research Center of Epdemiology and Microbiology, Gamaleya st. 18, Moscow 123098, Russia.ORCID 0000-0002-1168-4159
Vladimir ZhukhovitskyDepartment of Bacterial Infections, Gamaleya National Research Center of Epdemiology and Microbiology, Gamaleya st. 18, Moscow 123098, Russia.ORCID 0000-0002-4653-2446
Mikhail VasilievDepartment of Dusty Plasmas, Joint Institute for High Temperatures of the Russian Academy of Sciences, Moscow 125412, Russia.ORCID 0000-0002-0425-1152
Oleg PetrovDepartment of Dusty Plasmas, Joint Institute for High Temperatures of the Russian Academy of Sciences, Moscow 125412, Russia.
Svetlana ErmolaevaDepartment of Infections with Natural Foci, Gamaleya National Research Center of Epdemiology and Microbiology, Gamaleya st. 18, Moscow 123098, Russia.ORCID 0000-0003-3396-6816
Nailya ZigangirovaDepartment of Medical Microbiology, Gamaleya National Research Center of Epdemiology and Microbiology, Gamaleya st. 18, Moscow 123098, Russia.
Alexander GintsburgDepartment of Bacterial Genetics and Molecular Biology, Gamaleya National Research Center of Epdemiology and Microbiology, Gamaleya st. 18, Moscow 123098, Russia.

Funding

Ministry of Health of the Russian Federation 056-00083-25-02
6 · The paper itself

Abstract

BACKGROUND/

objectivesFluorothiazinone (FT), a small molecule of the 2,4-disubstituted-4H-[1,3,4]-thiadiazine-5-one class, is known to inhibit the type III secretion system (T3SS) in Gram-negative bacteria and has shown therapeutic potential in animal models and clinical trials. Given the evolutionary relationship between the T3SS and the bacterial flagellar apparatus, this study aimed to investigate the effects of FT on bacterial motility and flagellum assembly.

methodsMotility was assessed in

resultsFT inhibited motility of

conclusionsFT selectively inhibits flagellum-based motility in Gram-negative bacteria. Obtained data suggested FT interference with flagellum biosynthesis rather than disruption of rotation. Motility inhibition can contribute to FT therapeutic effects on Gram-negative bacterial infections.

Indexed as

anti-virulence agentbacterial motilityflagellum assemblyFluorothiazinoneGram-negative bacteriatype III secretion system

Identifiers

PMID40868014
PMCPMC12382710

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