ArticleAntibiotics (Basel, Switzerland)2025
Fluorescent Peptides Internalize HeLa Cells and Kill Multidrug-Resistant Clinical Bacterial Isolates.
Daniel Castellar-Almonacid, Kelin Johana Cuero-Amu, Jose David Mendoza-Mendoza, Natalia Ardila-Chantré, Fernando José Chavez-Salazar, Andrea Carolina Barragán-Cárdenas, Jhon Erick Rivera-Monroy, Claudia Parra-Giraldo, Zuly Jenny Rivera-Monroy, Javier García-Castañeda and 1 more
Abstract read
In one paragraphArticle in Antibiotics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Daniel Castellar-AlmonacidDepartamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia-Sede Bogotá, Carrera 45 No 26-85, Building 451, Bogotá D.C. 111321, Colombia.ORCID 0009-0005-1704-2842 Kelin Johana Cuero-AmuInstituto de Biotecnología, Facultad de Ciencias, Universidad Nacional de Colombia-Sede Bogotá, Carrera 45 No 26-85, Building 451, Bogotá D.C. 111321, Colombia.
Jose David Mendoza-MendozaInstituto de Biotecnología, Facultad de Ciencias, Universidad Nacional de Colombia-Sede Bogotá, Carrera 45 No 26-85, Building 451, Bogotá D.C. 111321, Colombia.ORCID 0009-0003-8448-1760 Natalia Ardila-ChantréDepartamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia-Sede Bogotá, Carrera 45 No 26-85, Building 451, Bogotá D.C. 111321, Colombia.ORCID 0000-0001-7491-4508 Fernando José Chavez-SalazarDepartamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia-Sede Bogotá, Carrera 45 No 26-85, Building 451, Bogotá D.C. 111321, Colombia.ORCID 0009-0001-3258-0877 Andrea Carolina Barragán-CárdenasBacteriología y Laboratorio Clínico, Facultad de Ciencias de la Salud, Universidad Colegio Mayor de Cundinamarca, Bogotá D.C. 110311, Colombia.ORCID 0000-0001-7545-8129 Jhon Erick Rivera-MonroyLaboratorio Instrumental de Alta Complejidad, Universidad de La Salle, Carrera 5 No. 59A-44, Bogotá D.C. 110231, Colombia.ORCID 0000-0002-6911-9988 Claudia Parra-GiraldoBiomedical Sciences Faculty, Universidad Europea, 28670 Madrid, Spain.
Zuly Jenny Rivera-MonroyDepartamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia-Sede Bogotá, Carrera 45 No 26-85, Building 451, Bogotá D.C. 111321, Colombia.ORCID 0000-0001-6915-8488 Javier García-CastañedaDepartamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia-Sede Bogotá, Carrera 45 No 26-85, Building 451, Bogotá D.C. 111321, Colombia.ORCID 0000-0001-6882-4397 Ricardo Fierro-MedinaDepartamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia-Sede Bogotá, Carrera 45 No 26-85, Building 451, Bogotá D.C. 111321, Colombia.
Funding
Ministerio de Ciencia, Tecnología e Innovación 845-2019
6 · The paper itselfAbstract
Palindromic antimicrobial peptides (PAMs) constitute versatile scaffolds for the design and optimization of anticancer agents with applications in therapy, diagnosis, and/or monitoring. In the present study, fluorolabeled peptides derived from the palindromic sequence RWQWRWQWR containing fluorescent probes, such as 2-Aminobenzoyl, 5(6)-Carboxyfluorescein, and Rhodamine B, were obtained. RP-HPLC analysis revealed that the palindromic peptide conjugated to Rhodamine B (RhB-RWQWRWQWR) exhibited the presence of isomers, likely corresponding to the open-ring and spiro-lactam forms of the fluorescent probe. This equilibrium is dependent on the peptide sequence, as the RP-HPLC analysis of dimeric peptide (RhB-RRWQWR-hF-KKLG)
Indexed as
cytoplasmic localizationLfcinBpeptide-based therapypeptide internalizationrhodamine labelingSPPS
Identifiers
PMID40867987
PMCPMC12383145
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390