Evaluating Antimicrobial Susceptibility Testing Methods for Cefiderocol: A Review and Expert Opinion on Current Practices and Future Directions.

Stefania Stefani, Fabio Arena, Luigi Principe, Stefano Stracquadanio, Chiara Vismara, Gian Maria Rossolini

Abstract readReview

In one paragraph

Review in Antibiotics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Emergence of ST383 carbapenem-resistantJAC-antimicrobial resistance · 2026
Article
Robust Goat-DerivedVeterinary sciences · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stefania StefaniDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95128 Catania, Italy.ORCID 0000-0003-1594-7427

Fabio ArenaDepartment of Clinical and Experimental Medicine, University of Foggia, 71100 Foggia, Italy.

Luigi PrincipeUOC Microbiologia e Virologia, Azienda Ospedaliera Bianchi-Melacrino-Morelli di Reggio Calabria, 89121 Reggio Calabria, Italy.ORCID 0000-0002-2000-5322

Stefano StracquadanioDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95128 Catania, Italy.ORCID 0000-0003-0653-9560

Chiara VismaraS.C. Microbiologia Clinica ASST Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy.ORCID 0009-0005-9538-088X

Gian Maria RossoliniDepartment of Experimental and Clinical, University of Florence, 50100 Florence, Italy.ORCID 0000-0002-9386-0434

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCefiderocol (FDC) presents challenges in antimicrobial susceptibility testing (AST). The reference standard is the broth microdilution (BMD) method with iron-depleted cation-adjusted Mueller-Hinton broth (ID-CAMHB). Still, it is cumbersome for routine clinical laboratory use, while variable accuracy has been reported with available commercial systems. Variability in interpretive criteria and areas of technical uncertainty (ATUs) further complicate assessments.

methodsThis review and expert opinion presents: (1) an overview of non-susceptibility to FDC and then delves into the performance of current FDC AST methods for Enterobacterales, RESULTS AND

conclusionsFor Enterobacterales, including carbapenem-resistant Enterobacterales (CRE), and

Indexed as

antimicrobial susceptibility testingcefiderocolclinical microbiology

Identifiers

PMID40867955

DOI10.3390/antibiotics14080760

PMCPMC12382653

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