Evidence map›Paper›PMID 40867923›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Using Integrated Bioinformatics Analysis to Identify Saponin Formosanin C as a Ferroptosis Inducer in Colorectal Cancer with p53 and Oncogenic KRAS.

Hsin-Chih Chen, Ching-Ying Chen, Pao-Yuan Wang, Pin-Yu Su, Shu-Ping Tsai, Chi-Pei Hsu, Hsiao-Sheng Liu, Chi-Ying F Huang, Wen-Hsing Cheng, Ming-Fen Lee and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hsin-Chih ChenDepartment of Human Development and Family Studies, National Taiwan Normal University, Taipei 10610, Taiwan.
Ching-Ying ChenGraduate Program of Nutrition Science, School of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.
Pao-Yuan WangGraduate Program of Nutrition Science, School of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.
Pin-Yu SuGraduate Program of Nutrition Science, School of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.
Shu-Ping TsaiGraduate Program of Nutrition Science, School of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.
Chi-Pei HsuGraduate Program of Nutrition Science, School of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.
Hsiao-Sheng LiuM.Sc. Program in Tropical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.ORCID 0000-0003-0576-7203
Chi-Ying F HuangInstitute of Biopharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 11211, Taiwan.
Wen-Hsing ChengDepartment of Nutrition and Food Sciences, Texas Woman's University, Denton, TX 76204, USA.
Ming-Fen LeeDepartment of Nutrition, China Medical University, Taichung 40678, Taiwan.
Chun-Li SuDepartment of Human Development and Family Studies, National Taiwan Normal University, Taipei 10610, Taiwan.ORCID 0000-0001-7617-2077

Funding

National Taiwan Normal University 10705, 10805, and 11106The Ministry of Science and Technology, Taiwan MOST 105-2320-B-003-003, 106-2320-B-003-006-MY3, and 109-2320-B-003-006-MY3
6 · The paper itself

Abstract

Ferroptosis, a form of cell death, is characterized by lipid peroxidation and is dependent on iron and reactive oxygen species (ROS). Here, through bioinformatics analysis, formosanin C was predicted to be a ferroptosis inducer in colorectal cancer (CRC) by suppressing antioxidation capacity. Indeed, formosanin C induced iron accumulation, lipid ROS formation, and ferroptosis in CRC. We found that

Indexed as

colorectal cancerdiosgenin saponin formosanin Cferroptosisgene analysisKRASp53

Identifiers

PMID40867923
PMCPMC12383135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.