Evidence map›Paper›PMID 40867854›Full record

ReviewAntioxidants (Basel, Switzerland)2025

Oxidative Stress in the Regulation of Autosis-Related Proteins.

María Guerra-Andrés, Inés Martínez-Rojo, Alejandra Piedra-Macías, Elena Lavado-Fernández, Marina García-Macia, Álvaro F Fernández

Abstract readReview
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Antioxidants (Basel, Switzerland) · 2026
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

María Guerra-AndrésDepartamento de Bioquímica y Biología Molecular, Universidad de Oviedo, 33006 Oviedo, Spain.
Inés Martínez-RojoInstituto de Biología Funcional y Genómica (IBFG), Universidad de Salamanca/CSIC, 37007 Salamanca, Spain.
Alejandra Piedra-MacíasDepartamento de Bioquímica y Biología Molecular, Universidad de Oviedo, 33006 Oviedo, Spain.
Elena Lavado-FernándezInstituto de Biología Funcional y Genómica (IBFG), Universidad de Salamanca/CSIC, 37007 Salamanca, Spain.
Marina García-MaciaInstituto de Biología Funcional y Genómica (IBFG), Universidad de Salamanca/CSIC, 37007 Salamanca, Spain.ORCID 0000-0002-3908-9060
Álvaro F FernándezDepartamento de Bioquímica y Biología Molecular, Universidad de Oviedo, 33006 Oviedo, Spain.ORCID 0000-0002-7704-4285

Funding

Junta de Castilla y León CL-EI-2021-08-IBFG Unit of ExcellenceMinisterio de Ciencia, Innovación y Universidades CNS2024-154954Ministerio de Ciencia, Innovación y Universidades PID2021-127534OB-I00Ministerio de Ciencia, Innovación y Universidades RYC2021-033684- 246 IMinisterio de Ciencia y Tecnología PID2022-138478OA-100Universidad de Oviedo PAPI-22-PF-21
6 · The paper itself

Abstract

Physiological levels of reactive oxygen species (ROS) play a crucial role as intracellular signaling molecules, helping to maintain cellular homeostasis. However, when ROS accumulate excessively, they become toxic to cells, leading to damage to lipids, proteins, and DNA. This oxidative stress can impair cellular function and lead to various forms of cell death, including apoptosis, necroptosis, ferroptosis, pyroptosis, paraptosis, parthanatos, and oxeiptosis. Despite their significance, the role of ROS in autosis (an autophagy-dependent form of cell death) remains largely unexplored. In this review, we gather current knowledge on autotic cell death and summarize how oxidative stress influences the activity of Beclin-1 and the Na

Indexed as

autophagyautosisBeclin-1Na+,K+-ATPaseoxidative stressROS

Identifiers

PMID40867854
PMCPMC12382736

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.