Evidence map›Paper›PMID 40867844›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Long-Term Neuroprotective Effects of Hydrogen-Rich Water and Memantine in Chronic Radiation-Induced Brain Injury: Behavioral, Histological, and Molecular Insights.

Kai Xu, Huan Liu, Yinhui Wang, Yushan He, Mengya Liu, Haili Lu, Yuhao Wang, Piye Niu, Xiujun Qin

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kai XuDepartment of Occupational and Environmental Health, School of Public Health, Capital Medical University, Beijing 100069, China.ORCID 0000-0002-2038-7156
Huan LiuChina Shanxi Key Laboratory of Drug Toxicology and Preclinical Studies for Radiopharmaceutical, Division of Radiation Medicine and Environmental Medicine, China Institute for Radiation Protection, Taiyuan 030006, China.
Yinhui WangChina Shanxi Key Laboratory of Drug Toxicology and Preclinical Studies for Radiopharmaceutical, Division of Radiation Medicine and Environmental Medicine, China Institute for Radiation Protection, Taiyuan 030006, China.
Yushan HeChina Shanxi Key Laboratory of Drug Toxicology and Preclinical Studies for Radiopharmaceutical, Division of Radiation Medicine and Environmental Medicine, China Institute for Radiation Protection, Taiyuan 030006, China.
Mengya LiuChina Shanxi Key Laboratory of Drug Toxicology and Preclinical Studies for Radiopharmaceutical, Division of Radiation Medicine and Environmental Medicine, China Institute for Radiation Protection, Taiyuan 030006, China.
Haili LuCollaborative Innovation Center for Molecular Imaging of Precision Medicine, Shanxi Medical University, Taiyuan 030006, China.
Yuhao WangChina Shanxi Key Laboratory of Drug Toxicology and Preclinical Studies for Radiopharmaceutical, Division of Radiation Medicine and Environmental Medicine, China Institute for Radiation Protection, Taiyuan 030006, China.
Piye NiuDepartment of Occupational and Environmental Health, School of Public Health, Capital Medical University, Beijing 100069, China.ORCID 0000-0002-0155-3438
Xiujun QinChina Shanxi Key Laboratory of Drug Toxicology and Preclinical Studies for Radiopharmaceutical, Division of Radiation Medicine and Environmental Medicine, China Institute for Radiation Protection, Taiyuan 030006, China.ORCID 0000-0002-0547-602X

Funding

Natural Science Foundation of Shanxi Province 202203021211005
6 · The paper itself

Abstract

Hydrogen-rich water (HRW) has shown neuroprotective effects in acute brain injury, but its role in chronic radiation-induced brain injury (RIBI) remains unclear. This study investigated the long-term efficacy of HRW in mitigating cognitive impairment and neuronal damage caused by chronic RIBI. Fifty male Sprague Dawley rats were randomly divided into five groups: control, irradiation (IR), IR with memantine, IR with HRW, and IR with combined treatment. All but the control group received 20 Gy whole-brain X-ray irradiation, followed by daily interventions for 60 days. Behavioral assessments, histopathological analyses, oxidative stress measurements,

Indexed as

CD44cognitive impairmenthydrogen-rich watermemantine hydrochlorideneuroprotectionradiation-induced brain injury

Identifiers

PMID40867844
PMCPMC12382694

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.