Evidence map›Paper›PMID 40867824›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Increased Exercise Tolerance in G6PD African Variant Mice Driven by Metabolic Adaptations and Erythrophagocytosis.

Francesca I Cendali, Abby L Grier, Christina Lisk, Monika Dzieciatkowska, Zachary Haiman, Julie A Reisz, Julie Harral, Daniel Stephenson, Ariel M Hay, Eric P Wartchow and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Francesca I CendaliDepartment of Biochemistry and Molecular Genetics, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-8874-2150
Abby L GrierDepartment of Biochemistry and Molecular Genetics, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-5199-8670
Christina LiskCardiovascular and Pulmonary Research Laboratory, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0001-6217-4063
Monika DzieciatkowskaDepartment of Biochemistry and Molecular Genetics, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
Zachary HaimanDepartment of Biochemistry and Molecular Genetics, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
Julie A ReiszDepartment of Biochemistry and Molecular Genetics, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
Julie HarralDepartment of Medicine, University of Colorado Denver, Aurora, CO 80045, USA.
Daniel StephensonDepartment of Biochemistry and Molecular Genetics, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
Ariel M HayDepartment of Pathology, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.ORCID 0000-0002-9003-6415
Eric P WartchowDepartment of Pathology, Children's Hospital Colorado, Aurora, CO 80045, USA.
Paul W BuehlerDepartment of Pathology, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.ORCID 0000-0003-0687-3008
Kirk C HansenDepartment of Biochemistry and Molecular Genetics, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
Travis NemkovDepartment of Biochemistry and Molecular Genetics, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0001-8566-7119
James C ZimringDepartment of Pathology, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.
David C IrwinCardiovascular and Pulmonary Research Laboratory, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-1743-8266
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-2258-6490

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS · 1995 to 2026
$32.6M
Translational Pulmonary Vascular Biology ProgramT32HL007171 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Sonia Castro Flores, Tim Lahm · 1985 to 2026
$9.4M
The Impact of Oxidative Stress on Erythocyte BiologyR01HL148151 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI D'ALESSANDRO, ANGELO, KARAFIN, MATTHEW S · 2019 to 2022
$8.9M
The role of ferroptosis in red cell aging in vivo and in vitroR01HL146442 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Angelo D'Alessandro, Adam N. Goldfarb · 2019 to 2026
$5.4M
The paradoxical response to iron in pulmonary hypertension of sickle cell diseaseR01HL161004 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BUEHLER, PAUL WERNER, D'ALESSANDRO, ANGELO · 2022 to 2025
$2.7M
Interactions between the ADORA2b/Sphk1axis and the AE1-Hb switch in red blood cell aging in vivo and in vitroR01HL149714 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI D'ALESSANDRO, ANGELO · 2020 to 2023
$2.6M
NHLBI NIH HHS R01 HL146442NHLBI NIH HHS R01 HL148151NHLBI NIH HHS R01 HL149714NHLBI NIH HHS R01 HL161004NHLBI NIH HHS T32 HL007171NIDDK NIH HHS P30 DK048520
6 · The paper itself

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) deficiency, the most common enzymatic disorder, affects over 500 million people worldwide and is often linked to exercise intolerance due to oxidative stress, but its true impact on physical performance remains unclear. This study aimed to evaluate the physiological and metabolic effects of G6PD deficiency on endurance capacity. Using humanized mice carrying the African G6PD variant [V68M; N126D] (hG6PD

Indexed as

critical speedexerciseG6PDhemolytic disordermetabolism

Identifiers

PMID40867824
PMCPMC12382757

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.