A Systematic Review of Genetic Variants in Glutathione S-Transferase Genes and Their Dual Role in SARS-CoV-2 Pathogenesis: From Acute Respiratory Complications to Long COVID.
Review in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors.
Valeria Villegas SánchezEscuela Superior de Medicina Programa de Maestría en Ciencias de la Salud, Instituto Politécnico Nacional, Mexico City 11340, Mexico.
Juan Luis Chávez PachecoLaboratorio de Farmacología, Instituto Nacional de Pediatría, Av. Insurgentes Sur 3700-Letra C, Coyoacán, Mexico City 04530, Mexico.ORCID 0000-0001-6919-4497
Margarita Isabel Palacios ArreolaDepartamento de Investigación en Toxicología y Medicina Ambiental, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Secretaría de Salud, Mexico City 14080, Mexico.ORCID 0000-0001-8882-7544
Martha Patricia Sierra-VargasDepartamento de Investigación en Toxicología y Medicina Ambiental, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Secretaría de Salud, Mexico City 14080, Mexico.ORCID 0000-0002-1894-745X
Luz Adriana Colín GodinezEscuela Superior de Medicina Programa de Maestría en Ciencias de la Salud, Instituto Politécnico Nacional, Mexico City 11340, Mexico.
Víctor Hugo Ahumada TopeteDepartamento de Epidemiología Hospitalaria e Infectología, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Calzada de Tlalpan 4502, Mexico City 14080, Mexico.
Rosario Fernández PlataLaboratorio de Investigación en Epidemiología e Infectología, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Calzada de Tlalpan 4502, Mexico City 14080, Mexico.ORCID 0000-0002-2971-0845
Anjarath Higuera-IglesiasLaboratorio de Investigación en Epidemiología e Infectología, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Calzada de Tlalpan 4502, Mexico City 14080, Mexico.ORCID 0000-0001-7034-9361
Roberto Lara-LemusDepartamento de Biomedicina Molecular e Investigación Traslacional, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas (INER), Mexico City 14080, Mexico.ORCID 0000-0001-5419-4283
Arnoldo Aquino-GálvezDepartamento de Fibrosis Pulmonar, Laboratorio de Biología Molecular, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Calzada de Tlalpan 4502, Mexico City 14080, Mexico.ORCID 0000-0002-2869-5516
Luz María Torres-EspíndolaLaboratorio de Farmacología, Instituto Nacional de Pediatría, Av. Insurgentes Sur 3700-Letra C, Coyoacán, Mexico City 04530, Mexico.ORCID 0000-0001-9929-9361
Manuel Castillejos-LópezLaboratorio de Investigación en Epidemiología e Infectología, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Calzada de Tlalpan 4502, Mexico City 14080, Mexico.
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
Oxidative stress (OS) occurs when there is an imbalance between oxidants and antioxidants, leading to disruptions in cellular signaling and causing damage to molecules. Glutathione S-transferase (GST) enzymes are crucial for maintaining redox balance by facilitating glutathione conjugation. Increased oxidative damage has been noted during the COVID-19 pandemic, and its persistence may be linked to the onset of long COVID. This systematic review aimed to assess the relationship between
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
A Systematic Review of Genetic Variants in Glutathione S-Transferase Genes and Their Dual Role in SARS-CoV-2 Pathogenesis: From Acute Respiratory Complications to Long COVID. · full record | OpenQuestion