Evidence map›Paper›PMID 40867730›Full record

ArticleAnimals : an open access journal from MDPI2025

Effect of Epidermal Growth Factor and 6-Dimethylaminopurine on In Vitro Maturation and Artificial Activation of Spix's Yellow-Toothed Cavy (

Leonardo V C Aquino, Samara L Olindo, Yara L F Silva, Vinícius D Silva, Lhara R M Oliveira, Moacir F Oliveira, Alexsandra F Pereira

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Leonardo V C AquinoLaboratory of Animal Biotechnology, Federal Rural University of the Semi-Arid, Mossoró 59625-900, RN, Brazil.ORCID 0000-0001-7192-7581
Samara L OlindoLaboratory of Animal Biotechnology, Federal Rural University of the Semi-Arid, Mossoró 59625-900, RN, Brazil.
Yara L F SilvaLaboratory of Animal Biotechnology, Federal Rural University of the Semi-Arid, Mossoró 59625-900, RN, Brazil.ORCID 0009-0004-7926-4777
Vinícius D SilvaLaboratory of Animal Biotechnology, Federal Rural University of the Semi-Arid, Mossoró 59625-900, RN, Brazil.
Lhara R M OliveiraLaboratory of Animal Biotechnology, Federal Rural University of the Semi-Arid, Mossoró 59625-900, RN, Brazil.
Moacir F OliveiraCenter of Multiplication of Wild Animals, Federal Rural University of the Semi-Arid, Mossoró 59625-900, RN, Brazil.
Alexsandra F PereiraLaboratory of Animal Biotechnology, Federal Rural University of the Semi-Arid, Mossoró 59625-900, RN, Brazil.ORCID 0000-0003-2137-854X

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 309078/2021-0Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001
6 · The paper itself

Abstract

The successful application of assisted reproductive technologies (ARTs), such as in vitro maturation (IVM) and artificial oocyte activation, requires species-specific adaptations. Although these methods are routinely used in laboratory rodents, their use in wild or non-model species remains limited, such as the Spix's yellow-toothed cavy, a Neotropical species of ecological and reproductive interest. This study evaluated the effects of different concentrations of epidermal growth factor (EGF; 10 or 50 ng/mL) on IVM (Experiment 1) and of 6-dimethylaminopurine (6-DMAP) on artificial oocyte activation (Experiment 2). EGF at 10 ng/mL (93.8% ± 1.6; 84.9% ± 0.7) promoted greater viability and less apoptosis in

Indexed as

embryonic developmentex situ conservationin vitro embryo productionneotropical rodentsoocyte viabilitywildlife

Identifiers

PMID40867730
PMCPMC12382800

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.