Evidence map›Paper›PMID 40867654›Full record

ArticleAnimals : an open access journal from MDPI2025

Pharmacokinetics of Tolfenamic Acid Administered Orally and Intravenously at Different Doses in Pekin Ducks (

Orhan Corum, Kamil Uney, Pedro Marin, Duygu Durna Corum, Devran Coskun, Elena Badillo, Muammer Elmas

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Orhan CorumDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Hatay 31060, Türkiye.ORCID 0000-0003-3168-2510
Kamil UneyDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, Konya 42031, Türkiye.ORCID 0000-0002-8674-4873
Pedro MarinDepartment of Pharmacology, Faculty of Veterinary Medicine, University of Murcia, 30100 Murcia, Spain.ORCID 0000-0003-4849-4452
Duygu Durna CorumDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Hatay 31060, Türkiye.ORCID 0000-0003-1567-991X
Devran CoskunDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Siirt, Siirt 56100, Türkiye.
Elena BadilloDepartment of Pharmacology, Faculty of Veterinary Medicine, University of Murcia, 30100 Murcia, Spain.ORCID 0000-0003-0888-4851
Muammer ElmasDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, Konya 42031, Türkiye.ORCID 0000-0001-9059-7151

Funding

The Coordination of Scientific Research Projects, University of Selcuk, Türkiye Project No. 23401154
6 · The paper itself

Abstract

This study aimed to examine the pharmacokinetic changes in tolfenamic acid administered intravenously and orally to ducks at different doses (2, 4, and 8 mg/kg). Furthermore, the binding ratio to plasma proteins was assessed utilizing the ultrafiltration method. Eighteen male Pekin ducks were randomly assigned to three dosage groups (2, 4, and 8 mg/kg), with each group undergoing a trial in two phases: intravenous (IV) and oral administration. The sample was analyzed using an approved HPLC-UV method. A non-compartmental analysis was utilized to evaluate the pharmacokinetic data. For 2 mg/kg IV injection, the area under the curve from zero to infinity (AUC

Indexed as

bioavailabilityducksNSAIDspharmacokineticsplasma protein bindingtolfenamic acid

Identifiers

PMID40867654
PMCPMC12382683

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.